Continuous neural control of a bionic limb restores biomimetic gait after amputation.

Autor: Song H; K. Lisa Yang Center for Bionics, Massachusetts Institute of Technology, Cambridge, MA, USA.; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, USA., Hsieh TH; K. Lisa Yang Center for Bionics, Massachusetts Institute of Technology, Cambridge, MA, USA.; Media Arts and Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA., Yeon SH; K. Lisa Yang Center for Bionics, Massachusetts Institute of Technology, Cambridge, MA, USA.; Media Arts and Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA., Shu T; K. Lisa Yang Center for Bionics, Massachusetts Institute of Technology, Cambridge, MA, USA.; Media Arts and Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA., Nawrot M; K. Lisa Yang Center for Bionics, Massachusetts Institute of Technology, Cambridge, MA, USA.; Mechanical Engineering Department, Massachusetts Institute of Technology, Cambridge, MA, USA., Landis CF; K. Lisa Yang Center for Bionics, Massachusetts Institute of Technology, Cambridge, MA, USA., Friedman GN; K. Lisa Yang Center for Bionics, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Israel EA; K. Lisa Yang Center for Bionics, Massachusetts Institute of Technology, Cambridge, MA, USA., Gutierrez-Arango S; K. Lisa Yang Center for Bionics, Massachusetts Institute of Technology, Cambridge, MA, USA.; Media Arts and Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA., Carty MJ; K. Lisa Yang Center for Bionics, Massachusetts Institute of Technology, Cambridge, MA, USA.; Division of Plastic and Reconstructive Surgery, Brigham and Women's Hospital, Boston, MA, USA., Freed LE; K. Lisa Yang Center for Bionics, Massachusetts Institute of Technology, Cambridge, MA, USA., Herr HM; K. Lisa Yang Center for Bionics, Massachusetts Institute of Technology, Cambridge, MA, USA. hherr@media.mit.edu.; Media Arts and Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA. hherr@media.mit.edu.; McGovern Institute, Massachusetts Institute of Technology, Cambridge, MA, USA. hherr@media.mit.edu.
Jazyk: angličtina
Zdroj: Nature medicine [Nat Med] 2024 Jul; Vol. 30 (7), pp. 2010-2019. Date of Electronic Publication: 2024 Jul 01.
DOI: 10.1038/s41591-024-02994-9
Abstrakt: For centuries scientists and technologists have sought artificial leg replacements that fully capture the versatility of their intact biological counterparts. However, biological gait requires coordinated volitional and reflexive motor control by complex afferent and efferent neural interplay, making its neuroprosthetic emulation challenging after limb amputation. Here we hypothesize that continuous neural control of a bionic limb can restore biomimetic gait after below-knee amputation when residual muscle afferents are augmented. To test this hypothesis, we present a neuroprosthetic interface consisting of surgically connected, agonist-antagonist muscles including muscle-sensing electrodes. In a cohort of seven leg amputees, the interface is shown to augment residual muscle afferents by 18% of biologically intact values. Compared with a matched amputee cohort without the afferent augmentation, the maximum neuroprosthetic walking speed is increased by 41%, enabling equivalent peak speeds to persons without leg amputation. Further, this level of afferent augmentation enables biomimetic adaptation to various walking speeds and real-world environments, including slopes, stairs and obstructed pathways. Our results suggest that even a small augmentation of residual muscle afferents restores biomimetic gait under continuous neuromodulation in individuals with leg amputation.
(© 2024. The Author(s).)
Databáze: MEDLINE
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