Comparison of digital and analog [ 68 Ga]Ga-PSMA-11 PET/CT for detecting post-prostatectomy biochemical recurrence in prostate cancer patients: a prospective study.

Autor: Kim YI; Department of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea., Lee DY; Department of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea., Sung C; Department of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea., Lee SJ; Department of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea., Oh SJ; Department of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea., Oh JS; Department of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea., Yoon S; Department of Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea., Lee JL; Department of Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea., Lim B; Department of Urology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea., Suh J; Department of Urology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea., Park J; Department of Urology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea., You D; Department of Urology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea., Jeong IG; Department of Urology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea., Hong JH; Department of Urology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea., Ahn H; Department of Urology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea., Kim CS; Department of Urology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea., Ryu JS; Department of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea. jsryu2@amc.seoul.kr.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2024 Jul 01; Vol. 14 (1), pp. 14989. Date of Electronic Publication: 2024 Jul 01.
DOI: 10.1038/s41598-024-65399-1
Abstrakt: Digital positron emission tomography/computed tomography (PET/CT) has shown enhanced sensitivity and spatial resolution compared with analog PET/CT. The present study compared the diagnostic performance of digital and analog PET/CT with [ 68 Ga]Ga-PSMA-11 in prostate cancer patients who experienced biochemical recurrence (BCR) after prostatectomy. Forty prostate cancer patients who experienced BCR, defined as serum prostate-specific antigen (PSA) concentrations exceeding 0.2 ng/mL after prostatectomy, were prospectively recruited. These patients were stratified into three groups based on their serum PSA levels. [ 68 Ga]Ga-PSMA-11 was injected into each patient, and images were acquired using both analog and digital PET/CT scanners. Analog and digital PET/CT showed comparable lesion detection rate (71.8% vs. 74.4%), sensitivity (85.0% vs. 90.0%), and positive predictive value (PPV, 100.0% vs. 100.0%). However, digital PET/CT detected more lesions (139 vs. 111) and had higher maximum standardized uptake values (SUVmax, 14.3 vs. 10.3) and higher kappa index (0.657 vs. 0.502) than analog PET/CT, regardless of serum PSA levels. On both analog and digital PET/CT, lesion detection rates and interrater agreement increased with increasing serum PSA levels. Compared with analog PET/CT, digital PET/CT detected more lesions with a higher SUVmax and better interrater agreement in prostate cancer patients who experienced BCR after prostatectomy.
(© 2024. The Author(s).)
Databáze: MEDLINE
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