Forces Shaping the Blastocyst.
| Autor: | Rozema D; Institut Curie, Université PSL, CNRS UMR3215, INSERM U934, 75005 Paris, France., Maître JL; Institut Curie, Université PSL, CNRS UMR3215, INSERM U934, 75005 Paris, France jean-leon.maitre@curie.fr. |
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| Jazyk: | angličtina |
| Zdroj: | Cold Spring Harbor perspectives in biology [Cold Spring Harb Perspect Biol] 2024 Jul 01. Date of Electronic Publication: 2024 Jul 01. |
| DOI: | 10.1101/cshperspect.a041519 |
| Abstrakt: | The blastocyst forms during the first days of mammalian development. The structure of the blastocyst is conserved among placental mammals and is paramount to the establishment of the first mammalian lineages. The blastocyst is composed of an extraembryonic epithelium, the trophectoderm (TE), that envelopes a fluid-filled lumen and the inner cell mass (ICM). To shape the blastocyst, embryos transit through three stages driven by forces that have been characterized in the mouse embryo over the past decade. The morphogenetically quiescent cleavage stages mask dynamic cytoskeletal remodeling. Then, during the formation of the morula, cells pull themselves together and the strongest ones internalize. Finally, the blastocyst forms after the pressurized lumen breaks the radial symmetry of the embryo before expanding in cycles of collapses and regrowth. In this review, we delineate the force patterns sculpting the blastocyst, based on our knowledge on the mouse and, to some extent, human embryos. (Copyright © 2024 Cold Spring Harbor Laboratory Press; all rights reserved.) |
| Databáze: | MEDLINE |
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