Association Between Genes in the Nuclear Factor E2-Related Factor 2 Antioxidative Response Elements Pathway and Cancer-Related Fatigue in Women With Early-Stage Breast Cancer.
| Autor: | Davis TS; National Cancer Institute., Koleck TA; Columbia University., Rosenzweig MQ; University of Pittsburgh., Miaskowski C; University of California, San Francisco., Erickson KI; AdventHealth Research Institute., Sereika SM; Associate professors School of Nursing, University of Pittsburgh, Pennsylvania., Bender CM; University of Pittsburgh., Conley YP; University of Pittsburgh. |
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| Jazyk: | angličtina |
| Zdroj: | Oncology nursing forum [Oncol Nurs Forum] 2024 Jun 14; Vol. 51 (4), pp. 404-416. |
| DOI: | 10.1188/24.ONF.404-416 |
| Abstrakt: | Objectives: To explore genes in the nuclear factor E2-related factor 2 antioxidative response elements (Nrf2-ARE) signaling pathway using a multiomics approach for associations with variability of cancer-related fatigue (CRF) in postmenopausal women with early-stage hormone receptor-positive breast cancer. Sample & Setting: Postmenopausal women (N = 116) with early-stage hormone receptor-positive breast cancer were recruited from western Pennsylvania. Methods & Variables: Candidate genes from the Nrf2-ARE pathway were investigated for associations with CRF occurrence and severity. Associations were evaluated using logistic regression for occurrence and linear regression for severity. Results: The rs2706110 TT genotype in NFE2L2 was associated with a 3.5-fold increase in odds of CRF occurrence. The cytosine-phosphate-guanine (CpG) site cg22820568 in PRDX1 was associated with CRF occurrence and severity. Implications for Nursing: Biomarkers based on Nrf2-ARE genes may help to identify women at increased risk for more severe CRF and to develop targeted interventions. |
| Databáze: | MEDLINE |
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