Imaging of colorectal adenomas with pseudoinvasion and malignant polyps using two-photon excitation microscopy.

Autor:	Florea MA; Pathology Department, Central University Emergency Military Hospital, Bucharest, Romania.; Pathology Department, University of Medicine and Pharmacy, Carol Davila', Bucharest, Romania., Eftimie LG; Pathology Department, Central University Emergency Military Hospital, Bucharest, Romania.; Center for Microscopy-Microanalysis and Information Processing, National University of Science and Technology Politehnica Bucharest, Bucharest, Romania.; Department of Special Motricity and Medical Recovery, The National University of Physical Education and Sports, Bucharest, Romania., Glogojeanu RR; Department of Special Motricity and Medical Recovery, The National University of Physical Education and Sports, Bucharest, Romania., Hristu R; Center for Microscopy-Microanalysis and Information Processing, National University of Science and Technology Politehnica Bucharest, Bucharest, Romania., Stanciu GA; Center for Microscopy-Microanalysis and Information Processing, National University of Science and Technology Politehnica Bucharest, Bucharest, Romania., Costache M; Pathology Department, University of Medicine and Pharmacy, Carol Davila', Bucharest, Romania.
Jazyk:	angličtina
Zdroj:	Frontiers in oncology [Front Oncol] 2024 Jun 14; Vol. 14, pp. 1394493. Date of Electronic Publication: 2024 Jun 14 (Print Publication: 2024).
DOI:	10.3389/fonc.2024.1394493
Abstrakt:	Introduction: Although the incidence and mortality rates of colorectal cancer exhibit significant variability, it remains one of the most prevalent cancers worldwide. Endeavors to prevent colorectal cancer development focus on detecting precursor lesions during colonoscopy. The diagnosis of endoscopically resected polyps relies on hematoxylin and eosin staining examination. For challenging cases like adenomatous polyps with epithelial misplacement, additional diagnostic methods could prove beneficial. Methods: This paper aims to underscore stromal changes observed in malignant polyps and polyps with pseudoinvasion, leveraging two-photon excitation microscopy (TPEM), a technique extensively employed in the medical field in recent years. Results and Discussions: Both the subjective and quantitative analysis of TPEM images revealed distinct distributions and densities of collagen at the invasion front in malignant polyps compared to areas of pseudoinvasion. TPEM holds potential in discerning true invasion in malignant polyps from pseudoinvasion, offering enhanced visualization of local stromal changes. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2024 Florea, Eftimie, Glogojeanu, Hristu, Stanciu and Costache.)
Databáze:	MEDLINE
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