A Study on the Behavior of Smart Starch- co -poly( N -isopropylacrylamide) Hybrid Microgels for Encapsulation of Methylene Blue.
| Autor: | da Costa Ribeiro A; Applied Physics in Materials Group, Departamento de Física, Universidade Estadual do Centro-Oeste, Guarapuava, PR 85040-167, Brazil., T Tominaga T; Applied Physics in Materials Group, Departamento de Física, Universidade Estadual do Centro-Oeste, Guarapuava, PR 85040-167, Brazil., Moretti Bonadio TG; Applied Physics in Materials Group, Departamento de Física, Universidade Estadual do Centro-Oeste, Guarapuava, PR 85040-167, Brazil., P da Silveira N; Post Graduation Program in Chemistry (PPGQ), Chemistry Institute, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS 91501-970, Brazil., C Leite D; Laboratório de Superfícies e Macromoléculas (SM Lab), Departamento de Física, Universidade Federal de Santa Maria, Santa Maria, RS 97105-900, Brazil. |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | ACS omega [ACS Omega] 2024 Jun 11; Vol. 9 (25), pp. 27349-27357. Date of Electronic Publication: 2024 Jun 11 (Print Publication: 2024). |
| DOI: | 10.1021/acsomega.4c01947 |
| Abstrakt: | Hybrid microgels made from starch nanoparticles (SNPs) and poly( N -isopropylacrylamide) p(NIPAM) were used as promising hosts for the methylene blue (MB) dye. In this paper, these thermoresponsive microgels were characterized by dynamic light scattering (DLS), zeta potential measurements (ZP), and scanning electron microscopy (SEM) and evaluated as carriers for skin-targeted drug delivery. The hybrid microgel-MB systems in PBS solution were also studied by UV-vis spectroscopy and DLS, revealing discernible differences in spectral intensity and absorption shifts compared to microgels devoid of MB. This underscores the successful integration of methylene blue within the SNPs- co -p(NIPAM) microgels, signifying their potential as efficacious drug delivery vehicles. Competing Interests: The authors declare no competing financial interest. (© 2024 The Authors. Published by American Chemical Society.) |
| Databáze: | MEDLINE |
| Externí odkaz: |
|