Severe Hypertrophic Cardiomyopathy Associated With Hydroxychloroquine in a Young Woman With Systemic Lupus Erythematosus: A Case Report and Review of the Literature.
| Autor: | Brown B; Internal Medicine, Downstate-Health Science University, Brooklyn, USA., Joseph C; Cardiology, Downstate-Health Science University, Brooklyn, USA., Talanki V; Cardiology, Downstate-Health Science University, Brooklyn, USA., Budzikowski AS; Cardiovascular Medicine - Electrophysiology (EP) Section, Downstate-Health Science University, Brooklyn, USA., McFarlane SI; Internal Medicine, Downstate-Health Science University, Brooklyn, USA., John S; Cardiology, Downstate-Health Science University, Brooklyn, USA. |
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| Jazyk: | angličtina |
| Zdroj: | Cureus [Cureus] 2024 May 31; Vol. 16 (5), pp. e61452. Date of Electronic Publication: 2024 May 31 (Print Publication: 2024). |
| DOI: | 10.7759/cureus.61452 |
| Abstrakt: | The use of the antimalarial drug hydroxychloroquine is a standard treatment in patients with systemic lupus erythematosus. It helps reduce disease-associated damage, prevents disease flare, and improves overall survival. The mechanism of action of hydroxychloroquine includes interference with lysosomal degradation of cells leading to the accumulation of vacuoles. Retinopathy is a well-described adverse effect of hydroxychloroquine, thus requiring screening with an ophthalmologist after prolonged use. Although rarely reported, cardiac adverse effects of hydroxychloroquine can also occur. In this report, we present a case of a 23-year-old woman with systemic lupus erythematosus on hydroxychloroquine who presented with stroke possibly due to Libman-Sacks endocarditis and was found to have severe hypertrophic cardiomyopathy on transthoracic echocardiogram. Competing Interests: Human subjects: Consent was obtained or waived by all participants in this study. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. (Copyright © 2024, Brown et al.) |
| Databáze: | MEDLINE |
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