Unmasking Carcinoid Syndrome in a Chronic Obstructive Pulmonary Disease (COPD) Patient: A Rare Presentation with Wheezing and Angioedema.
| Autor: | Aleksanyan M; Internal Medicine, Capital Health Regional Medical Center, Trenton, USA., Chadalawada S; Internal Medicine, Capital Health Regional Medical Center, Trenton, USA., Hakobyan K; Internal Medicine, Capital Health Regional Medical Center, Trenton, USA., Yang X; Pathology and Laboratory Medicine, Capital Health Regional Medical Center, Trenton, USA., Chen E; Hematology and Medical Oncology, Capital Health Regional Medical Center, Trenton, USA. |
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| Jazyk: | angličtina |
| Zdroj: | Cureus [Cureus] 2024 May 29; Vol. 16 (5), pp. e61321. Date of Electronic Publication: 2024 May 29 (Print Publication: 2024). |
| DOI: | 10.7759/cureus.61321 |
| Abstrakt: | Carcinoid syndrome is a rare condition resulting from neuroendocrine tumors (NETs) that secrete vasoactive substances like serotonin. This report describes the case of a 61-year-old man with a history of chronic obstructive pulmonary disease (COPD) and hypertension who presented with new-onset angioedema, loss of consciousness, and a fall. He had been treated for COPD exacerbations during ER visits without improvement and was unaware of a prior mesenteric carcinoid tumor diagnosis from 2012. The next emergency evaluation revealed significant airway and facial edema necessitating intubation. Imaging and biopsy identified a well-differentiated grade 1 NET with extensive liver metastases. Laboratory tests showed elevated levels of serum serotonin, chromogranin A, and 24-hour urine 5-hydroxyindoleacetic acid (5-HIAA). Post-discharge, a PET scan confirmed metastatic lesions primarily in the liver and small bowel, with an unresectable mesenteric mass. The patient was treated with lanreotide and became symptom-free. This case underscores the need to consider carcinoid syndrome in patients with COPD presenting with unexplained respiratory symptoms, as timely diagnosis and treatment can significantly enhance patient outcomes. Competing Interests: Human subjects: Consent was obtained or waived by all participants in this study. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. (Copyright © 2024, Aleksanyan et al.) |
| Databáze: | MEDLINE |
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