Gap junctions fine-tune ganglion cell signals to equalize response kinetics within a given electrically coupled array.

Autor:	Szarka G; University of Pécs, Szentágothai Research Centre, Pécs, Hungary.; University of Pécs, Department of Neurobiology, Pécs, Hungary.; MTA-PTE NAP 2 Retinal Electrical Synapses Research Group, Pécs, Hungary.; Center for Neuroscience, University of Pécs, Pécs, Hungary.; SzKK Imaging Core Facility, Szentágothai Research Centre, University of Pécs, Pécs, Hungary., Ganczer A; University of Pécs, Szentágothai Research Centre, Pécs, Hungary.; University of Pécs, Department of Neurobiology, Pécs, Hungary.; MTA-PTE NAP 2 Retinal Electrical Synapses Research Group, Pécs, Hungary.; Center for Neuroscience, University of Pécs, Pécs, Hungary., Balogh M; University of Pécs, Szentágothai Research Centre, Pécs, Hungary.; University of Pécs, Department of Neurobiology, Pécs, Hungary.; MTA-PTE NAP 2 Retinal Electrical Synapses Research Group, Pécs, Hungary.; Center for Neuroscience, University of Pécs, Pécs, Hungary., Tengölics ÁJ; University of Pécs, Szentágothai Research Centre, Pécs, Hungary.; University of Pécs, Department of Neurobiology, Pécs, Hungary.; MTA-PTE NAP 2 Retinal Electrical Synapses Research Group, Pécs, Hungary.; Center for Neuroscience, University of Pécs, Pécs, Hungary., Futácsi A; University of Pécs, Szentágothai Research Centre, Pécs, Hungary.; MTA-PTE NAP 2 Retinal Electrical Synapses Research Group, Pécs, Hungary.; Center for Neuroscience, University of Pécs, Pécs, Hungary.; SzKK Imaging Core Facility, Szentágothai Research Centre, University of Pécs, Pécs, Hungary., Kenyon G; Los Alamos National Laboratory, Los Alamos, NM, USA., Pan F; The Hong Kong Polytechnic University, Hong Kong, China., Kovács-Öller T; University of Pécs, Szentágothai Research Centre, Pécs, Hungary.; University of Pécs, Department of Neurobiology, Pécs, Hungary.; MTA-PTE NAP 2 Retinal Electrical Synapses Research Group, Pécs, Hungary.; Center for Neuroscience, University of Pécs, Pécs, Hungary.; SzKK Imaging Core Facility, Szentágothai Research Centre, University of Pécs, Pécs, Hungary., Völgyi B; University of Pécs, Szentágothai Research Centre, Pécs, Hungary.; University of Pécs, Department of Neurobiology, Pécs, Hungary.; MTA-PTE NAP 2 Retinal Electrical Synapses Research Group, Pécs, Hungary.; Center for Neuroscience, University of Pécs, Pécs, Hungary.
Jazyk:	angličtina
Zdroj:	IScience [iScience] 2024 May 24; Vol. 27 (6), pp. 110099. Date of Electronic Publication: 2024 May 24 (Print Publication: 2024).
DOI:	10.1016/j.isci.2024.110099
Abstrakt:	Retinal ganglion cells (RGCs) summate inputs and forward a spike train code to the brain in the form of either maintained spiking (sustained) or a quickly decaying brief spike burst (transient). We report diverse response transience values across the RGC population and, contrary to the conventional transient/sustained scheme, responses with intermediary characteristics are the most abundant. Pharmacological tests showed that besides GABAergic inhibition, gap junction (GJ)-mediated excitation also plays a pivotal role in shaping response transience and thus visual coding. More precisely GJs connecting RGCs to nearby amacrine and RGCs play a defining role in the process. These GJs equalize kinetic features, including the response transience of transient OFF alpha (tOFFα) RGCs across a coupled array. We propose that GJs in other coupled neuron ensembles in the brain are also critical in the harmonization of response kinetics to enhance the population code and suit a corresponding task. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (© 2024 The Authors.)
Databáze:	MEDLINE
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