A causal link between autoantibodies and neurological symptoms in long COVID.

Autor:	Santos Guedes de Sa K; Department of Immunobiology, Yale School of Medicine, Center for Infection and Immunity, New Haven, CT, USA.; Center for Infection and Immunity, Yale School of Medicine, New Haven, CT, USA., Silva J; Department of Immunobiology, Yale School of Medicine, Center for Infection and Immunity, New Haven, CT, USA.; Center for Infection and Immunity, Yale School of Medicine, New Haven, CT, USA., Bayarri-Olmos R; Department of Immunobiology, Yale School of Medicine, Center for Infection and Immunity, New Haven, CT, USA.; Center for Infection and Immunity, Yale School of Medicine, New Haven, CT, USA., Brinda R; Department of Immunobiology, Yale School of Medicine, Center for Infection and Immunity, New Haven, CT, USA.; Center for Infection and Immunity, Yale School of Medicine, New Haven, CT, USA., Alec Rath Constable R; Department of Immunobiology, Yale School of Medicine, Center for Infection and Immunity, New Haven, CT, USA.; Center for Infection and Immunity, Yale School of Medicine, New Haven, CT, USA., Colom Diaz PA; Department of Immunobiology, Yale School of Medicine, Center for Infection and Immunity, New Haven, CT, USA.; Center for Infection and Immunity, Yale School of Medicine, New Haven, CT, USA., Kwon DI; Department of Immunobiology, Yale School of Medicine, Center for Infection and Immunity, New Haven, CT, USA.; Center for Infection and Immunity, Yale School of Medicine, New Haven, CT, USA.; Howard Hughes Medical Institute, Chevy Chase, MD, USA., Rodrigues G; Department of Immunobiology, Yale School of Medicine, Center for Infection and Immunity, New Haven, CT, USA.; Center for Infection and Immunity, Yale School of Medicine, New Haven, CT, USA., Wenxue L; Center for Infection and Immunity, Yale School of Medicine, New Haven, CT, USA.; Yale Cancer Biology Institute, Yale University, West Haven, CT, USA., Baker C; Department of Immunobiology, Yale School of Medicine, Center for Infection and Immunity, New Haven, CT, USA.; Center for Infection and Immunity, Yale School of Medicine, New Haven, CT, USA., Bhattacharjee B; Department of Immunobiology, Yale School of Medicine, Center for Infection and Immunity, New Haven, CT, USA.; Center for Infection and Immunity, Yale School of Medicine, New Haven, CT, USA., Wood J; Cohen Center for Recovery from Complex Chronic Illness, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Tabacof L; Cohen Center for Recovery from Complex Chronic Illness, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Liu Y; Center for Infection and Immunity, Yale School of Medicine, New Haven, CT, USA.; Yale Cancer Biology Institute, Yale University, West Haven, CT, USA., Putrino D; Cohen Center for Recovery from Complex Chronic Illness, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Horvath TL; Department of Neuroscience, Yale University School of Medicine, New Haven, CT 06520., Iwasaki A; Department of Immunobiology, Yale School of Medicine, Center for Infection and Immunity, New Haven, CT, USA.; Center for Infection and Immunity, Yale School of Medicine, New Haven, CT, USA.; Howard Hughes Medical Institute, Chevy Chase, MD, USA.
Jazyk:	angličtina
Zdroj:	MedRxiv : the preprint server for health sciences [medRxiv] 2024 Jun 19. Date of Electronic Publication: 2024 Jun 19.
DOI:	10.1101/2024.06.18.24309100
Abstrakt:	Acute SARS-CoV-2 infection triggers the generation of diverse and functional autoantibodies (AABs), even after mild cases. Persistently elevated autoantibodies have been found in some individuals with long COVID (LC). Using a >21,000 human protein array, we identified diverse AAB targets in LC patients that correlated with their symptoms. Elevated AABs to proteins in the nervous system were found in LC patients with neurocognitive and neurological symptoms. Purified Immunoglobulin G (IgG) samples from these individuals reacted with human pons tissue and were cross-reactive with mouse sciatic nerves, spinal cord, and meninges. Antibody reactivity to sciatic nerves and meninges correlated with patient-reported headache and disorientation. Passive transfer of IgG from patients to mice led to increased sensitivity and pain, mirroring patient-reported symptoms. Similarly, mice injected with IgG showed loss of balance and coordination, reflecting donor-reported dizziness. Our findings suggest that targeting AABs could benefit some LC patients. Competing Interests: Declaration of interests A. I. co-founded RIGImmune, Xanadu Bio and PanV and is a member of the Board of Directors of Roche Holding Ltd and Genentech. All other authors declare no competing interests.
Databáze:	MEDLINE
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