Molecular epidemiology of recurrent zoonotic transmission of mpox virus in West Africa.

Autor:	Djuicy DD; Virology Service, Centre Pasteur du Cameroun, 451 Rue 2005, Yaounde 2, P.O. Box 1274., Omah IF; Institute of Ecology and Evolution, University of Edinburgh, The King's Buildings, Edinburgh EH9 3FL, UK.; Department of Parasitology and Entomology, Nnamdi Azikiwe University, Awka, Nigeria., Parker E; African Center of Excellence for Genomics of Infectious Diseases, Redeemer's University, Ede, Osun State, Nigeria.; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA., Tomkins-Tinch CH; The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Otieno JR; Theiagen Genomics, Highlands Ranch, CO, USA., Yifomnjou MHM; Virology Service, Centre Pasteur du Cameroun, 451 Rue 2005, Yaounde 2, P.O. Box 1274., Essengue LLM; Virology Service, Centre Pasteur du Cameroun, 451 Rue 2005, Yaounde 2, P.O. Box 1274., Ayinla AO; African Center of Excellence for Genomics of Infectious Diseases, Redeemer's University, Ede, Osun State, Nigeria., Sijuwola AE; African Center of Excellence for Genomics of Infectious Diseases, Redeemer's University, Ede, Osun State, Nigeria., Ahmed MI; African Center of Excellence for Genomics of Infectious Diseases, Redeemer's University, Ede, Osun State, Nigeria., Ope-Ewe OO; African Center of Excellence for Genomics of Infectious Diseases, Redeemer's University, Ede, Osun State, Nigeria., Ogunsanya OA; African Center of Excellence for Genomics of Infectious Diseases, Redeemer's University, Ede, Osun State, Nigeria., Olono A; African Center of Excellence for Genomics of Infectious Diseases, Redeemer's University, Ede, Osun State, Nigeria., Eromon P; African Center of Excellence for Genomics of Infectious Diseases, Redeemer's University, Ede, Osun State, Nigeria., Yonga MGW; Virology Service, Centre Pasteur du Cameroun, 451 Rue 2005, Yaounde 2, P.O. Box 1274., Essima GD; Virology Service, Centre Pasteur du Cameroun, 451 Rue 2005, Yaounde 2, P.O. Box 1274., Touoyem IP; Virology Service, Centre Pasteur du Cameroun, 451 Rue 2005, Yaounde 2, P.O. Box 1274., Mounchili LJM; Virology Service, Centre Pasteur du Cameroun, 451 Rue 2005, Yaounde 2, P.O. Box 1274., Eyangoh SI; Virology Service, Centre Pasteur du Cameroun, 451 Rue 2005, Yaounde 2, P.O. Box 1274., Esso L; Department for the Control of Disease, Epidemics and Pandemics, Ministry of Public Health, Yaounde, Cameroon., Nguidjol IME; Department for the Control of Disease, Epidemics and Pandemics, Ministry of Public Health, Yaounde, Cameroon., Metomb SF; Department for the Control of Disease, Epidemics and Pandemics, Ministry of Public Health, Yaounde, Cameroon., Chebo C; Department for the Control of Disease, Epidemics and Pandemics, Ministry of Public Health, Yaounde, Cameroon., Agwe SM; Department for the Control of Disease, Epidemics and Pandemics, Ministry of Public Health, Yaounde, Cameroon., Mossi HM; Department for the Control of Disease, Epidemics and Pandemics, Ministry of Public Health, Yaounde, Cameroon., Bilounga CN; Department for the Control of Disease, Epidemics and Pandemics, Ministry of Public Health, Yaounde, Cameroon., Etoundi AGM; Virology Service, Centre Pasteur du Cameroun, 451 Rue 2005, Yaounde 2, P.O. Box 1274., Akanbi O; Nigeria Centre for Disease Control and Prevention., Abuja, Nigeria., Egwuenu A; Nigeria Centre for Disease Control and Prevention., Abuja, Nigeria., Ehiakhamen O; Nigeria Centre for Disease Control and Prevention., Abuja, Nigeria., Chukwu C; Nigeria Centre for Disease Control and Prevention., Abuja, Nigeria., Suleiman K; Nigeria Centre for Disease Control and Prevention., Abuja, Nigeria., Akinpelu A; Nigeria Centre for Disease Control and Prevention., Abuja, Nigeria., Ahmad A; Nigeria Centre for Disease Control and Prevention., Abuja, Nigeria., Imam KI; Nigeria Centre for Disease Control and Prevention., Abuja, Nigeria., Ojedele R; Nigeria Centre for Disease Control and Prevention., Abuja, Nigeria., Oripenaye V; Nigeria Centre for Disease Control and Prevention., Abuja, Nigeria., Ikeata K; Nigeria Centre for Disease Control and Prevention., Abuja, Nigeria., Adelakun S; Nigeria Centre for Disease Control and Prevention., Abuja, Nigeria., Olajumoke B; Nigeria Centre for Disease Control and Prevention., Abuja, Nigeria., O'Toole Á; Institute of Ecology and Evolution, University of Edinburgh, The King's Buildings, Edinburgh EH9 3FL, UK., Magee A; Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA., Zeller M; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA., Gangavarapu K; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA., Varilly P; The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Park DJ; The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Mboowa G; Africa Centres for Disease Control and Prevention (Africa CDC),Addis Ababa, Ethiopia., Tessema SK; Africa Centres for Disease Control and Prevention (Africa CDC),Addis Ababa, Ethiopia., Tebeje YK; Africa Centres for Disease Control and Prevention (Africa CDC),Addis Ababa, Ethiopia., Folarin O; African Center of Excellence for Genomics of Infectious Diseases, Redeemer's University, Ede, Osun State, Nigeria.; Department of Biological Sciences, Redeemer's University, Ede, Osun State, Nigeria., Happi A; African Center of Excellence for Genomics of Infectious Diseases, Redeemer's University, Ede, Osun State, Nigeria., Lemey P; Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, Leuven, Belgium., Suchard MA; Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.; Department of Biomathematics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.; Department of Biostatistics, Fielding School of Public Health, University of California, Los Angeles, Los Angeles, CA 90095, USA., Andersen KG; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.; Scripps Research Translational Institute, La Jolla, CA 92037, USA., Sabeti P; The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Department of Immunology and Infectious Diseases, Harvard T H Chan School of Public Health, Boston, MA 02115, USA., Rambaut A; Institute of Ecology and Evolution, University of Edinburgh, The King's Buildings, Edinburgh EH9 3FL, UK., Ihekweazu C; Nigeria Centre for Disease Control and Prevention., Abuja, Nigeria., Jide I; Nigeria Centre for Disease Control and Prevention., Abuja, Nigeria., Adetifa I; Nigeria Centre for Disease Control and Prevention., Abuja, Nigeria., Njoum R; Virology Service, Centre Pasteur du Cameroun, 451 Rue 2005, Yaounde 2, P.O. Box 1274., Happi CT; African Center of Excellence for Genomics of Infectious Diseases, Redeemer's University, Ede, Osun State, Nigeria.; Department of Biological Sciences, Redeemer's University, Ede, Osun State, Nigeria.; Department of Immunology and Infectious Diseases, Harvard T H Chan School of Public Health, Boston, MA 02115, USA.
Jazyk:	angličtina
Zdroj:	MedRxiv : the preprint server for health sciences [medRxiv] 2024 Jun 19. Date of Electronic Publication: 2024 Jun 19.
DOI:	10.1101/2024.06.18.24309115
Abstrakt:	Nigeria and Cameroon reported their first mpox cases in over three decades in 2017 and 2018 respectively. The outbreak in Nigeria is recognised as an ongoing human epidemic. However, owing to sparse surveillance and genomic data, it is not known whether the increase in cases in Cameroon is driven by zoonotic or sustained human transmission. Notably, the frequency of zoonotic transmission remains unknown in both Cameroon and Nigeria. To address these uncertainties, we investigated the zoonotic transmission dynamics of the mpox virus (MPXV) in Cameroon and Nigeria, with a particular focus on the border regions. We show that in these regions mpox cases are still driven by zoonotic transmission of a newly identified Clade IIb.1. We identify two distinct zoonotic lineages that circulate across the Nigeria-Cameroon border, with evidence of recent and historic cross border dissemination. Our findings support that the complex cross-border forest ecosystems likely hosts shared animal populations that drive cross-border viral spread, which is likely where extant Clade IIb originated. We identify that the closest zoonotic outgroup to the human epidemic circulated in southern Nigeria in October 2013. We also show that the zoonotic precursor lineage circulated in an animal population in southern Nigeria for more than 45 years. This supports findings that southern Nigeria was the origin of the human epidemic. Our study highlights the ongoing MPXV zoonotic transmission in Cameroon and Nigeria, underscoring the continuous risk of MPXV (re)emergence. Competing Interests: Competing interest declaration MAS received grants and contracts from the U.S. Food & Drug Administration, the U.S. Department of Veterans Affairs and Johnson & Johnson outside the scope of this work.
Databáze:	MEDLINE
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