Gene expression differences associated with intrinsic hindfoot muscle loss in the jerboa, Jaculus jaculus.

Autor: Tran MP; Department of Cell and Developmental Biology, University of California San Diego, La Jolla, California, USA., Ochoa Reyes D; Department of Cell and Developmental Biology, University of California San Diego, La Jolla, California, USA., Weitzel AJ; Department of Cell and Developmental Biology, University of California San Diego, La Jolla, California, USA., Saxena A; Department of Cell and Developmental Biology, University of California San Diego, La Jolla, California, USA., Hiller M; LOEWE Centre for Translational Biodiversity Genomics, Frankfurt, Germany.; Senckenberg Research Institute, Frankfurt, Germany.; Faculty of Biosciences, Goethe University Frankfurt, Frankfurt, Germany., Cooper KL; Department of Cell and Developmental Biology, University of California San Diego, La Jolla, California, USA.
Jazyk: angličtina
Zdroj: Journal of experimental zoology. Part B, Molecular and developmental evolution [J Exp Zool B Mol Dev Evol] 2024 Nov; Vol. 342 (7), pp. 453-464. Date of Electronic Publication: 2024 Jul 01.
DOI: 10.1002/jez.b.23268
Abstrakt: Vertebrate animals that run or jump across sparsely vegetated habitats, such as horses and jerboas, have reduced the number of distal limb bones, and many have lost most or all distal limb muscle. We previously showed that nascent muscles are present in the jerboa hindfoot at birth and that these myofibers are rapidly and completely lost soon after by a process that shares features with pathological skeletal muscle atrophy. Here, we apply an intra- and interspecies differential RNA-Seq approach, comparing jerboa and mouse muscles, to identify gene expression differences associated with the initiation and progression of jerboa hindfoot muscle loss. We show evidence for reduced hepatocyte growth factor and fibroblast growth factor signaling and an imbalance in nitric oxide signaling; all are pathways that are necessary for skeletal muscle development and regeneration. We also find evidence for phagosome formation, which hints at how myofibers may be removed by autophagy or by nonprofessional phagocytes without evidence for cell death or immune cell activation. Last, we show significant overlap between genes associated with jerboa hindfoot muscle loss and genes that are differentially expressed in a variety of human muscle pathologies and rodent models of muscle loss disorders. All together, these data provide molecular insight into the process of evolutionary and developmental muscle loss in jerboa hindfeet.
(© 2024 The Author(s). Journal of Experimental Zoology Part B: Molecular and Developmental Evolution published by Wiley Periodicals LLC.)
Databáze: MEDLINE
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