FAK inhibitors in cancer, a patent review - an update on progress.
| Autor: | Ye YX; Institute of Pharmaceutical Biotechnology, School of Biology and Food Engineering, Suzhou University, Suzhou, PR China., Cao YY; State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, PR China., Xu LS; Institute of Pharmaceutical Biotechnology, School of Biology and Food Engineering, Suzhou University, Suzhou, PR China., Wang HC; Institute of Pharmaceutical Biotechnology, School of Biology and Food Engineering, Suzhou University, Suzhou, PR China., Liu XH; Institute of Pharmaceutical Biotechnology, School of Biology and Food Engineering, Suzhou University, Suzhou, PR China.; School of Pharmacy, Anhui Province Key Laboratory of Major Autoimmune Diseases, Anhui Institute of Innovative Drugs, Anhui Medical University, Hefei, PR China., Zhu HL; State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, PR China. |
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| Jazyk: | angličtina |
| Zdroj: | Expert opinion on therapeutic patents [Expert Opin Ther Pat] 2024 Aug; Vol. 34 (8), pp. 593-610. Date of Electronic Publication: 2024 Jul 02. |
| DOI: | 10.1080/13543776.2024.2368742 |
| Abstrakt: | Introduction: Focal adhesion kinase (FAK) is a cytoplasmic non-receptor tyrosine kinase over-expressed in various malignancies which is related to various cellular functions such as adhesion, metastasis and proliferation. Areas Covered: There is growing evidence that FAK is a promising therapeutic target for designing inhibitors by regulating the downstream pathways of FAK. Some potential FAK inhibitors have entered clinical phase research. Expert Opinion: FAK could be an effective target in medicinal chemistry research and there were a variety of FAKIs have been patented recently. Here, we updated an overview of design, synthesis and structure-activity relationship of chemotherapeutic FAK inhibitors (FAKIs) from 2017 until now based on our previous work. We hope our efforts can broaden the understanding of FAKIs and provide new ideas and insights for future cancer treatment from medicinal chemistry point of view. |
| Databáze: | MEDLINE |
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