Vitamin D status in female dogs with mammary gland tumors.

Autor: Pineda C; Departamento de Medicina y Cirugía Animal, University of Córdoba, Córdoba, Spain.; Hospital Clínico Veterinario, University of Córdoba, Córdoba, Spain., Raya AI; Departamento de Medicina y Cirugía Animal, University of Córdoba, Córdoba, Spain.; Hospital Clínico Veterinario, University of Córdoba, Córdoba, Spain., Morgaz J; Departamento de Medicina y Cirugía Animal, University of Córdoba, Córdoba, Spain.; Hospital Clínico Veterinario, University of Córdoba, Córdoba, Spain., Sánchez-Céspedes R; Departamento de Anatomía y Anatomía Patológica Comparadas y Toxicología, University of Córdoba, Córdoba, Spain., Millán Y; Departamento de Anatomía y Anatomía Patológica Comparadas y Toxicología, University of Córdoba, Córdoba, Spain., Aguilera-Tejero E; Departamento de Medicina y Cirugía Animal, University of Córdoba, Córdoba, Spain.; Hospital Clínico Veterinario, University of Córdoba, Córdoba, Spain., López I; Departamento de Medicina y Cirugía Animal, University of Córdoba, Córdoba, Spain.; Hospital Clínico Veterinario, University of Córdoba, Córdoba, Spain.
Jazyk: angličtina
Zdroj: Journal of veterinary internal medicine [J Vet Intern Med] 2024 Jul-Aug; Vol. 38 (4), pp. 2257-2264. Date of Electronic Publication: 2024 Jul 01.
DOI: 10.1111/jvim.17137
Abstrakt: Background: Little information exists about vitamin D status in bitches with mammary tumors.
Objectives: To determine whether low plasma vitamin D concentrations are found in bitches with mammary tumors.
Animals: Eighty-five client-owned bitches with mammary tumors (n = 21 benign, n = 64 malignant) and 39 age-matched healthy bitches.
Methods: Case-control study. Plasma ionized and total calcium, phosphorus, magnesium, urea, creatinine, albumin, total proteins, alanine aminotransferase, alkaline phosphatase, parathyroid hormone (PTH), calcitriol (1,25-dihydroxyvitamin D), and 25-hydroxyvitamin D concentrations were measured in all bitches at the time of clinical diagnosis and before any treatments. Statistical analysis was performed to compare variables among groups (control, benign, and malignant).
Results: No significant differences were found when plasma 25-hydroxyvitamin D concentrations in bitches with malignant (148.9 [59.9] ng/mL) and benign mammary tumors (150.1 [122.3] ng/mL) were compared with control group (129.9 [54.5] ng/mL). Parathyroid hormone was significantly higher in bitches with malignant (19.9 [20.5] pg/mL), and benign mammary tumors (14.6 [14.9] pg/mL) compared with control group (7.5 [7.5] pg/mL; P < .01). Only the presence of mammary tumors (P < .01) and age (P = .04; adjusted R 2  = .22) was significant in predicting PTH.
Conclusions: Bitches with mammary tumors do not have low 25-hydroxyvitamin D concentrations thus vitamin D supplementation is unlikely to be useful for prevention of mammary tumors in bitches.
(© 2024 The Author(s). Journal of Veterinary Internal Medicine published by Wiley Periodicals LLC on behalf of American College of Veterinary Internal Medicine.)
Databáze: MEDLINE
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