Histopathological risk assessment in multisite epithelial dysplasia: A meta-analysis.

Autor: Ferraz DLF; Oral Diagnosis Department, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, São Paulo, Brazil., Dos Santos ES; Oral Diagnosis Department, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, São Paulo, Brazil., Pedroso CM; Oral Diagnosis Department, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, São Paulo, Brazil., Silva BSF; Department of Stomatologic Sciences, School of Dentistry, Federal University of Goiás, Goiânia, Goiás, Brazil., Kujan O; UWA Dental School, The University of Western Australia, Nedlands, Western Australia, Australia., Salo TA; Oral Medicine and Pathology, Research Unit of Population Health, University of Oulu, Oulu, Finland.; Medical Research Center and Oulu University Hospital, Oulu, Finland.; Department of Oral and Maxillofacial Diseases, University of Helsinki, Helsinki, Finland.; Translational Immunology Research Program (TRIMM) and iCAN Digital Precision Cancer Medicine Flagship, University of Helsinki, Helsinki, Finland.; Department of Pathology, Helsinki University Hospital, Helsinki, Finland., Malki MI; Pathology Unit, Department of Basic Medical Sciences, College of Medicine, QU Health, Qatar University, Doha, Qatar., Juteau S; Department of Pathology, Haartman Institute, University of Helsinki and HUSLAB, Helsinki, Finland., Vargas PA; Oral Diagnosis Department, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, São Paulo, Brazil., Lopes MA; Oral Diagnosis Department, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, São Paulo, Brazil., Santos-Silva AR; Oral Diagnosis Department, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, São Paulo, Brazil.
Jazyk: angličtina
Zdroj: Oral diseases [Oral Dis] 2024 Nov; Vol. 30 (8), pp. 4821-4829. Date of Electronic Publication: 2024 Jun 30.
DOI: 10.1111/odi.15052
Abstrakt: Objective: Histopathological grading of oral epithelial dysplasia (OED) is the current standard for stratifying cancer progression risk but is associated with subjectivity and variability. This problem is not commonly seen regarding the grading of epithelial dysplasia in other sites. This systematic review aims to compare grading systems for oral, anal, penile, and cervical epithelial dysplasia to determine their predictive accuracy for recurrence and malignant transformation (MT) outcomes.
Methods: The review protocol was registered in PROSPERO (CRD42023403035) and was reported according to the PRISMA checklist. A comprehensive search was performed in the main databases and gray literature. The risk of bias in individual studies was analyzed using the Joanna Briggs Institute checklist for each study design.
Results: Forty-six studies were deemed eligible and included in this systematic review, of which 45 were included in the quantitative analysis. Meta-analysis revealed that the binary system demonstrated a higher predictive ability for MT/recurrence of OED compared to multilevel systems. Higher predictive accuracy of MT was also observed for binary grading systems in anal intraepithelial neoplasia.
Conclusions: No significant difference was found between the current grading systems of epithelial dysplasia in different body parts. However, binary grading systems have shown better clinical outcomes.
(© 2024 Wiley Periodicals LLC.)
Databáze: MEDLINE
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