Serotonin receptor-mediated vasorelaxation occurs primarily through 5-HT 4 activation in bovine lateral saphenous vein.
Autor: | Trotta RJ; Department of Animal and Food Sciences, University of Kentucky, Lexington, Kentucky, USA., Harmon DL; Department of Animal and Food Sciences, University of Kentucky, Lexington, Kentucky, USA., Klotz JL; Forage-Animal Production Research Unit, USDA-ARS, Lexington, Kentucky, USA. |
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Jazyk: | angličtina |
Zdroj: | Physiological reports [Physiol Rep] 2024 Jul; Vol. 12 (13), pp. e16128. |
DOI: | 10.14814/phy2.16128 |
Abstrakt: | To better understand mechanisms of serotonin- (5-HT) mediated vasorelaxation, isolated lateral saphenous veins from cattle were assessed for vasoactivity using myography in response to increasing concentrations of 5-HT or selective 5-HT receptor agonists. Vessels were pre-contracted with 1 × 10 -4 M phenylephrine and exposed to increasing concentrations of 5-HT or 5-HT receptor agonists that were selective for 5-HT (© 2024 The Author(s). Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society. This article has been contributed to by U.S. Government employees and their work is in the public domain in the USA.) |
Databáze: | MEDLINE |
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