New Clerodane Diterpenoids from Tinospora Capillipes with Antibacterial and Anti-Inflammatory Properties.

Autor: Song YZ; Zibo Hospital of Traditional Chinese Medicine, Zibo, 255000, China., Yuan C; Zoucheng Administration for Market Regulation, Zoucheng, 273100, China., Li WJ; Clinical laboratory,Disease Prevention and Control Center of Yanzhou District, Jining, 272100, China., Song QJ; Zibo Hospital of Traditional Chinese Medicine, Zibo, 255000, China., Zhu WH; Zibo Hospital of Traditional Chinese Medicine, Zibo, 255000, China., Zhang J; School of Biological Science and Technology, University of Jinan, Jinan, 250022, China.
Jazyk: angličtina
Zdroj: Chemistry & biodiversity [Chem Biodivers] 2024 Sep; Vol. 21 (9), pp. e202401033. Date of Electronic Publication: 2024 Aug 19.
DOI: 10.1002/cbdv.202401033
Abstrakt: Four new clerodane diterpenoids, namely tinocapills A-D (1-4), and one known analogue (5) were isolated from the roots of Tinospora capillipes in the present study. The structures of these new compounds, including their absolute configurations, were determined through a combination of detailed spectroscopic analysis and theoretical statistical approaches, including electronic circular dichroism (ECD) analyses and quantum mechanical (QM)-NMR methods. Additionally, the stereostructure of 5 was confirmed via X-ray diffraction analysis. Furthermore, all these isolates were evaluated for their antibacterial and anti-inflammatory activities. Compounds 1, 2 and 5 demonstrated antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) with MICs ranging from 4-64 μg/mL, and compounds 3 and 4 exhibited potential anti-inflammatory effects by suppressing LPS-induced TNF-α and NO releases in RAW264.7 cells.
(© 2024 Wiley-VHCA AG, Zurich, Switzerland.)
Databáze: MEDLINE
Externí odkaz: