The Pathophysiology of Portal Hypertension.

Autor:	Ramkissoon R; Department of Gastroenterology & Hepatology, Mayo Clinic, 200 1st Street, SW, Rochester, MN 55902, USA., Cao S; Mayo College of Medicine, Mayo Clinic, 200 1st Street, SW, Rochester, MN 55902, USA., Shah VH; Department of Gastroenterology & Hepatology, Mayo Clinic, 200 1st Street, SW, Rochester, MN 55902, USA; Department of Internal Medicine, Mayo Clinic, 200 1st Street, SW, Rochester, MN 55902, USA. Electronic address: shah.vijay@mayo.edu.
Jazyk:	angličtina
Zdroj:	Clinics in liver disease [Clin Liver Dis] 2024 Aug; Vol. 28 (3), pp. 369-381. Date of Electronic Publication: 2024 Apr 27.
DOI:	10.1016/j.cld.2024.03.001
Abstrakt:	This article reviews the pathophysiology of portal hypertension that includes multiple mechanisms internal and external to the liver. This article starts with a review of literature describing the cellular and molecular mechanisms of portal hypertension, microvascular thrombosis, sinusoidal venous congestion, portal angiogenesis, vascular hypocontractility, and hyperdynamic circulation. Mechanotransduction and the gut-liver axis, which are newer areas of research, are reviewed. Dysfunction of this axis contributes to chronic liver injury, inflammation, fibrosis, and portal hypertension. Sequelae of portal hypertension are discussed in subsequent studies. Competing Interests: Disclosure The authors have no financial or commercial disclosure. (Copyright © 2024 Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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