Implementation and Performance of a Point-of-Care COVID-19 Test Program in 4000 California Schools.

Autor: Le Marchand C; Center for Infectious Disease, California Department of Public Health, Richmond, CA. Electronic address: Chloe.LeMarchand@cdph.ca.gov., Rizzo K; Center for Infectious Disease, California Department of Public Health, Richmond, CA., Nakamura R; Center for Laboratory Services, California Department of Public Health, Richmond, CA., Bornstein L; Center for Infectious Disease, California Department of Public Health, Richmond, CA., Bardach NS; Department of Pediatrics, University of California San Francisco, San Francisco, CA., Pritchard D; Center for Infectious Disease, California Department of Public Health, Richmond, CA., Medlin S; Center for Infectious Disease, California Department of Public Health, Richmond, CA., Ahmed A; Center for Infectious Disease, California Department of Public Health, Richmond, CA., Cornejo M; Center for Laboratory Services, California Department of Public Health, Richmond, CA., Moser L; Center for Infectious Disease, California Department of Public Health, Richmond, CA., Bakhtar O; Department of Pathology, Sharp Healthcare, San Diego, CA., Silver LD; Public Health Institute, Oakland, CA., Iton A; The California Endowment, Los Angeles, CA., May L; Department of Emergency Medicine, University of California Davis, Sacramento, CA., Kimsey P; Center for Laboratory Services, California Department of Public Health, Richmond, CA., Sud SR; Center for Infectious Disease, California Department of Public Health, Richmond, CA., Pan E; Center for Infectious Disease, California Department of Public Health, Richmond, CA; Department of Pediatrics, University of California San Francisco, San Francisco, CA., Jacobson K; Center for Infectious Disease, California Department of Public Health, Richmond, CA., Glaser C; Center for Laboratory Services, California Department of Public Health, Richmond, CA.
Jazyk: angličtina
Zdroj: The Journal of pediatrics [J Pediatr] 2024 Nov; Vol. 274, pp. 114178. Date of Electronic Publication: 2024 Jun 28.
DOI: 10.1016/j.jpeds.2024.114178
Abstrakt: Objective: To evaluate the feasibility and accuracy of an unprecedented COVID-19 antigen testing program in schools, which required a healthcare provider order, laboratory director, a Clinical Laboratory Improvement Amendments certificate of waiver, as well as training of school personnel.
Study Design: Descriptive report of a point-of-care, school-based antigen testing program in California from August 1st, 2021 through May 30, 2022, in which participants grades K-12 self-swabbed and school personnel performed testing. Participants included 944 009 students, personnel, and community members from 4022 California kindergarten through high schools. Outcomes measured include sensitivity and specificity (with polymerase chain reaction [PCR] as comparator) of the Abbott BinaxNOW antigen test, number of tests performed, and active infections identified.
Results: Of 102 022 paired PCR/antigen tests, the overall sensitivity and specificity for the antigen test was 81.2% (95% CI: 80.5%-81.8%) and 99.6% (95% CI: 99.5%-99.6%), respectively, using cycle threshold values <30. During January through March 2022, the highest prevalence period, the positive predictive value of antigen testing was 94.7% and the negative predictive value was 94.2%. Overall, 4022 school sites were enrolled and 3 987 840 million antigen tests were performed on 944 009 individuals. A total of 162 927 positive antigen tests were reported in 135 163 individuals (14.3% of persons tested).
Conclusions: Rapidly implementing a school-based testing program in thousands of schools is feasible. Self-swabbing and testing by school personnel can yield accurate results. On-site COVID-19 testing is no longer necessary in schools, but this model provides a framework for future infectious disease threats.
Competing Interests: Declaration of Competing Interest Funding for the pilot program was provided through the Public Health Institute with support from the California Endowment and the Chan-Zuckerberg Initiative (grant 2021-232540). Funding for the statewide antigen testing program was through support from a CDC Epidemiology and Laboratory Capacity grant (NU50CK000539-02-09)(43) CDPH statewide antigen testing program included all California counties except LA county who received their own ELC funding grant. The other authors declare no conflicts of interest.
(Published by Elsevier Inc.)
Databáze: MEDLINE
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