Mimosa/quince seed mucilage-co-poly (methacrylate) hydrogels for controlled delivery of capecitabine: Simulation studies, characterization and toxicological evaluation.

Autor: Yasmin T; Faculty of Pharmacy, The University of Lahore, Lahore 54000, Pakistan., Mahmood A; Faculty of Pharmacy, The University of Lahore, Lahore 54000, Pakistan; Department of Pharmacy, University of Chakwal, Chakwal 48800, Pakistan. Electronic address: asif.mahmood@uoc.edu.pk., Sarfraz RM; College of Pharmacy, University of Sargodha, Sargodha 40100, Pakistan., Rehman U; College of Pharmacy, University of Sargodha, Sargodha 40100, Pakistan., Boublia A; Laboratoire de Physico-Chimie des Hauts Polymères (LPCHP), Département de Génie des Procédés, Faculté de Technologie, Université Ferhat ABBAS Sétif-1, Sétif 19000, Algeria., Alkahtani AM; Department of Microbiology & Clinical Parasitology College of Medicine, King Khalid University, Abha 61411, Saudi Arabia., Albakri GS; Department of Teaching and Learning, College of Education and Human Development, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia., Ijaz H; Department of Pharmaceutical Sciences, Pak-Austria Fachhochschule Institute of Applied Sciences and Technology, Mang, Khanpur Road, Haripur 22620, Pakistan., Ahmed S; Department of Chemistry, University of Chakwal, 48800, Pakistan., Harron B; College of Pharmacy, University of Sargodha, Sargodha 40100, Pakistan., Albrahim M; Chemical Engineering Department, College of Engineering, University of Ha'il, P.O. Box 2440, Ha'il 81441, Saudi Arabia., Elboughdiri N; Chemical Engineering Department, College of Engineering, University of Ha'il, P.O. Box 2440, Ha'il 81441, Saudi Arabia; Chemical Engineering Process Department, National School of Engineers Gabes, University of Gabes, Street Omar ibn El-Khattab, 6029, Gabes, Tunisia., Yadav KK; Faculty of Science and Technology, Madhyanchal Professional University, Ratibad, Bhopal 462044, India; Environmental and Atmospheric Sciences Research Group, Scientific Research Center, Al-Ayen University, Thi-Qar, Nasiriyah 64001, Iraq., Benguerba Y; Laboratoire de Biopharmacie Et Pharmacotechnie (LBPT), Ferhat Abbas Setif 1 University, Setif, Algeria. Electronic address: yacinebenguerba@univ-setif.dz.
Jazyk: angličtina
Zdroj: International journal of biological macromolecules [Int J Biol Macromol] 2024 Aug; Vol. 275 (Pt 1), pp. 133468. Date of Electronic Publication: 2024 Jun 28.
DOI: 10.1016/j.ijbiomac.2024.133468
Abstrakt: This research focused on developing pH-regulated intelligent networks using quince and mimosa seed mucilage through aqueous polymerization to sustain Capecitabine release while overcoming issues like short half-life, high dosing frequency, and low bioavailability. The resulting MSM/QSM-co-poly(MAA) hydrogel was evaluated for several parameters, including complex structure formation, stability, pH sensitivity, morphology, and elemental composition. FTIR, DSC, and TGA analyses confirmed the formation of a stable, complex cross-linked network, demonstrating excellent stability at elevated temperatures. SEM analysis revealed the hydrogels' smooth, fine texture with porous surfaces. PXRD and EDX results indicated the amorphous dispersion of Capecitabine within the network. The QMM9 formulation achieved an optimal Capecitabine loading of 87.17 %. The gel content of the developed formulations ranged from 65.21 % to 90.23 %. All formulations exhibited excellent swelling behavior, with ratios between 65.91 % and 91.93 % at alkaline pH. In vitro dissolution studies indicated that up to 98 % of Capecitabine was released after 24 h at pH 7.4, demonstrating the potential for sustained release. Furthermore, toxicological evaluation in healthy rabbits confirmed the system's safety, non-toxicity, and biocompatibility.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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