Diet Optimization in Inflammatory Bowel Disease: Impact on Disease Relapse and Inflammatory Markers. A 1-year Prospective Trial.

Autor:	Preda CM; Carol Davila University of Medicine and Pharmacy, Department of Gastroenterology and Hepatology, Fundeni Clinical Institute, Bucharest, Romania. . carmenmonica.preda@gmail.com., Istratescu D; Carol Davila University of Medicine and Pharmacy, Department of Gastroenterology and Hepatology, Fundeni Clinical Institute, Bucharest, Romania. . doina.proca08@gmail.com., Nitescu M; Carol Davila University of Medicine and Pharmacy, National Institute for Infectious Diseases Prof. Dr. Matei Bals, Bucharest, Romania. maria.nitescu@umfcd.ro., Manuc T; Carol Davila University of Medicine and Pharmacy, Department of Gastroenterology and Hepatology, Fundeni Clinical Institute, Bucharest, Romania. teodora.manuc@gmail.com., Manuc M; Carol Davila University of Medicine and Pharmacy, Department of Gastroenterology and Hepatology, Fundeni Clinical Institute, Bucharest, Romania. m_manuc@yahoo.com., Stroie T; Carol Davila University of Medicine and Pharmacy, Department of Gastroenterology and Hepatology, Fundeni Clinical Institute, Bucharest, Romania. stroie.tudor@gmail.com., Tieranu C; Department of Gastroenterology and Hepatology, Elias Emergency Hospital, Bucharest, Romania. tieranucristian@yahoo.com., Meianu CG; Carol Davila University of Medicine and Pharmacy, Department of Gastroenterology and Hepatology, Fundeni Clinical Institute, Bucharest, Romania. corina_meianu@yahoo.com., Andrei A; Department of Gastroenterology and Hepatology, Fundeni Clinical Institute, Bucharest, Romania. sandrei741@yahoo.com., Ciora CA; Department of Gastroenterology and Hepatology, Fundeni Clinical Institute, Bucharest, Romania. cioracsz@yahoo.com., Louis E; Department of Gastroenterology, University Hospital CHU Liège, Belgium. Edouard.Louis@uliege.be., Diculescu M; Carol Davila University of Medicine and Pharmacy, Department of Gastroenterology and Hepatology, Fundeni Clinical Institute, Bucharest, Romania. mmdiculescu@yahoo.com.
Jazyk:	angličtina
Zdroj:	Journal of gastrointestinal and liver diseases : JGLD [J Gastrointestin Liver Dis] 2024 Jun 29; Vol. 33 (2), pp. 184-193. Date of Electronic Publication: 2024 Jun 29.
DOI:	10.15403/jgld-5482
Abstrakt:	Background and Aims: Recent research has shown that Western-style diets have been associated with an increased risk of inflammatory bowel diseases (IBD). Our aim was to examine the link between an anti-inflammatory diet and the maintenance of IBD remission, as well as to assess the potential therapeutic advantages of this dietary approach in preserving IBD remission. Methods: The inclusion and exclusion criteria were applied to a total of 189 individuals with IBD, with 21 individuals not meeting the criteria. Therefore, 168 eligible patients were enrolled in the study and allocated to either an anti-inflammatory diet or a regular diet, based on their personal preference. Results: A cohort of 168 IBD adult patients was recruited for the study: 88 patients with ulcerative colitis and 80 with Crohn's disease. The intervention group received an anti-inflammatory diet consisting of the removal of red and processed meat, fried foods, high-lactose foods, fast food, white bread, sugar, and vegetable oils rich in omega-6 for a period of 1 year. The clinical response was maintained in 80 patients (95.2%) in the intervention group and in 72 patients (85.7%) in the control group (p-value=0.036). Although not statistically significant, fecal calprotectin was higher in the control group than in the intervention group at follow-up. Conclusions: Patients who adhered to an anti-inflammatory diet exhibited a higher rate of maintenance of clinical remission. Furthermore, improvement in inflammation tests was observed in the intervention group, reinforcing the proposition that IBD is a lifestyle-related disease.
Databáze:	MEDLINE
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