Cardiac computed tomography-derived coronary artery volume to myocardial mass in patients with severe coronary artery disease.

Autor: Kageyama S; University of Galway, Galway, Ireland., Taylor CA; HeartFlow, California, USA., Updegrove A; HeartFlow, California, USA., Garg S; Department of Cardiology, Royal Blackburn Hospital, Blackburn, United Kingdom., Masuda S; University of Galway, Galway, Ireland., Revaiah PC; University of Galway, Galway, Ireland., Kageyama M; University of Galway, Galway, Ireland., Tsai TY; University of Galway, Galway, Ireland., Miyashita K; University of Galway, Galway, Ireland., Tobe A; University of Galway, Galway, Ireland., Tanaka K; Department of Radiology, University Hospital Brussels, Belgium., De Mey J; Universitair Ziekenhuis Brussel, VUB, Brussels, Belgium., La Meir M; Universitair Ziekenhuis Brussel, VUB, Brussels, Belgium., Schneider U; Department of Cardiothoracic Surgery, University Hospital Jena, Germany., Doenst T; Department of Cardiothoracic Surgery, University Hospital Jena, Germany., Teichgräber U; Department of Radiology, University Hospital Jena, Germany., Saima M; Centro Cardiologico Monzino, IRCCS Monzino, Italy., Pompilio G; Centro Cardiologico Monzino, IRCCS Monzino, Italy; Department of Biomedical, Surgical and Dental Sciences, University of Milan, Milano, Italy., Andreini D; Division of Cardiology and Cardiac Imaging, IRCCS Galeazzi Sant'Ambrogio, Milan, Italy; Department of Biomedical and Clinical Sciences, University of Milan, Italy., Pontone G; Centro Cardiologico Monzino, IRCCS Monzino, Italy; Department of Biomedical, Surgical and Dental Sciences, University of Milan, Milano, Italy., Puskas JD; Department of Cardiothoracic Surgery, Emory University Hospital Midtown, USA., Gupta H; Department of Radiology, The Valley Hospital, Ridgewood, NJ, USA., Morel MA; University of Galway, Galway, Ireland., Serruys PW; University of Galway, Galway, Ireland. Electronic address: patrick.w.j.c.serruys@gmail.com., Onuma Y; University of Galway, Galway, Ireland. Electronic address: yoshinobu.onuma@universityofgalway.ie.
Jazyk: angličtina
Zdroj: Journal of cardiovascular computed tomography [J Cardiovasc Comput Tomogr] 2024 Sep-Oct; Vol. 18 (5), pp. 478-488. Date of Electronic Publication: 2024 Jun 28.
DOI: 10.1016/j.jcct.2024.06.010
Abstrakt: Background: Coronary artery lumen volume (V) to myocardial mass (M) ratio (V/M) can show the mismatch between epicardial coronary arteries and the underlying myocardium.
Methods: The V, M and V/M were obtained from the coronary computed tomography angiography (CCTA) of patients in the FAST-TRACK CABG study, the first-in-human trial of coronary artery bypass grafting (CABG) guided solely by CCTA and fractional flow reserve derived from CCTA (FFR CT ) in patients with complex coronary artery disease (CAD). The correlations between V/M ratios and baseline characteristics were determined and compared with those from the ADVANCE registry, an unselected cohort of historical controls with chronic CAD.
Results: The V/M ratio was obtained in 106 of the 114 pre-CABG CCTAs. Mean age was 65.6 years and 87% of them were male. The anatomical SYNTAX score from CCTA was significantly higher than the functional SYNTAX score derived using FFR CT [43.1 (15.2) vs 41.1 (16.5), p ​< ​0.001]. Mean V, M, and V/M were 2204 ​mm 3 , 137 ​g, and 16.5 ​mm 3 /g, respectively. There were weak negative correlations between V and anatomical and functional SYNTAX scores (Pearson's r ​= ​-0.26 and -0.34). V and V/M had a strong correlation (r ​= ​0.82). The V/M ratio in the current study was significantly lower than that in the ADVANCE registry (median 16.1 vs. 24.8 [1st quartile 20.1]).
Conclusion: Systematically smaller V/M ratios were found in this population with severe CAD requiring CABG compared to an unselected cohort with chronic CAD. The V/M ratio could provide additional non-invasive assessment of CAD especially when combined with FFR CT .
Competing Interests: Declaration of competing interest Dr Serruys has received consultancy fees from Philips/Volcano, SMT, Novartis, Xeltis, Merillife. Dr Garg receives consulting fee from Biosensors. Dr Puskas reports consulting fees from Medtronic, Atricure, Medistim, Edwards Life Science, and royalty payments from Scanlan. Dr Gupta reports an institutional grant from Siemens Health Solutions. Dr Garg reported consulting fees from Biosensors. Dr Taylor and Dr Rogers are employees of HeatFlow Inc. including salary and equity. Dr Thomsen is an employee of GE HealthCare. Dr Pontone reports grants and consultant fees from GE HealthCare, Bracco, and HeartFlow, Payment honoraria from GE HealthCare and HeartFlow, and payment for expert testimony from GE HealthCare. All other authors have no conflict of interest to declare. All other authors have no conflict of interest to declare.
(Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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