Evaluating Danish Breast Cancer Group locoregional radiotherapy guideline adherence in clinical treatment data 2008-2016: The DBCG RT Nation study.

Autor: Refsgaard L; Department of Experimental Clinical Oncology, Aarhus University Hospital, Denmark; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark. Electronic address: lasref@rm.dk., Skarsø Buhl E; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark; Danish Center for Particle Therapy, Aarhus University Hospital, Aarhus, Denmark., Yates E; Department of Oncology, Aarhus University Hospital, Aarhus, Denmark., Maae E; Department of Oncology, Vejle Hospital, University Hospital of Southern Denmark, Denmark., Berg M; Department of Oncology, Vejle Hospital, University Hospital of Southern Denmark, Denmark., Al-Rawi S; Department of Oncology, Zealand University Hospital, Department of Clinical Oncology and Palliative Care, Næstved, Denmark., Saini A; Department of Oncology, Zealand University Hospital, Department of Clinical Oncology and Palliative Care, Næstved, Denmark., Vestmø Maraldo M; Department of Oncology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark., Boye K; Department of Oncology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark., Louise Holm Milo M; Department of Oncology, Aalborg University Hospital, Aalborg, Denmark; Department of Clinical Medicine, Faculty of Medicine, Aalborg University, Aalborg, Denmark., Jensen I; Department of Oncology, Aalborg University Hospital, Aalborg, Denmark., Wichmann Matthiessen L; Department of Oncology, Copenhagen University Hospital - Herlev and Gentofte, Copenhagen, Denmark., Nørring Bekke S; Department of Oncology, Copenhagen University Hospital - Herlev and Gentofte, Copenhagen, Denmark., Holck Nielsen M; Laboratory of Radiation Physics, Department of Oncology, Odense University Hospital, Odense, Denmark; Department of Oncology, Odense University Hospital, Odense, Denmark., Laugaard Lorenzen E; Laboratory of Radiation Physics, Department of Oncology, Odense University Hospital, Odense, Denmark., Bech Jellesmark Thorsen L; Department of Experimental Clinical Oncology, Aarhus University Hospital, Denmark; Department of Oncology, Aarhus University Hospital, Aarhus, Denmark., Sofia Korreman S; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark; Danish Center for Particle Therapy, Aarhus University Hospital, Aarhus, Denmark., Vrou Offersen B; Department of Experimental Clinical Oncology, Aarhus University Hospital, Denmark; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark; Danish Center for Particle Therapy, Aarhus University Hospital, Aarhus, Denmark; Department of Oncology, Aarhus University Hospital, Aarhus, Denmark.
Jazyk: angličtina
Zdroj: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology [Radiother Oncol] 2024 Oct; Vol. 199, pp. 110289. Date of Electronic Publication: 2024 Jun 28.
DOI: 10.1016/j.radonc.2024.110289
Abstrakt: Background and Purpose: Guideline adherence in radiotherapy is crucial for maintaining treatment quality and consistency, particularly in non-trial patient settings where most treatments occur. The study aimed to assess the impact of guideline changes on treatment planning practices and compare manual registry data accuracy with treatment planning data.
Materials and Methods: This study utilised the DBCG RT Nation cohort, a collection of breast cancer radiotherapy data in Denmark, to evaluate adherence to guidelines from 2008 to 2016. The cohort included 7448 high-risk breast cancer patients. National guideline changes included, fractionation, introduction of respiratory gating, irradiation of the internal mammary lymph nodes, use of the simultaneous integrated boost technique and inclusion of the Left Anterior Descending coronary artery in delineation practice. Methods for structure name mapping, laterality detection, detection of temporal changes in population mean lung volume, and dose evaluation were presented and applied. Manually registered treatment characteristic data was obtained from the Danish Breast Cancer Database for comparison.
Results: The study found immediate and consistent adherence to guideline changes across Danish radiotherapy centres. Treatment practices before guideline implementation were documented and showed a variation among centres. Discrepancies between manual registry data and actual treatment planning data were as high as 10% for some measures.
Conclusion: National guideline changes could be detected in the routine treatment data, with a high degree of compliance and short implementation time. Data extracted from treatment planning data files provides a more accurate and detailed characterisation of treatments and guideline adherence than medical register data.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024. Published by Elsevier B.V.)
Databáze: MEDLINE
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