Etiology of the Neonatal Hypoglycemias.

Autor: Stanley CA; Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA; Division of Endocrinology and Diabetes, Children's Hospital of Philadelphia, Philadelphia, PA, USA., De Leon DD; Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA; Division of Endocrinology and Diabetes, Children's Hospital of Philadelphia, Philadelphia, PA, USA. Electronic address: deleon@chop.edu.
Jazyk: angličtina
Zdroj: Advances in pediatrics [Adv Pediatr] 2024 Aug; Vol. 71 (1), pp. 119-134. Date of Electronic Publication: 2024 Apr 23.
DOI: 10.1016/j.yapd.2024.03.001
Abstrakt: To provide a more appropriate foundation for dealing with the problem of hypoglycemia in newborn infants, this article focuses on the mechanisms which underlie the various forms of neonatal hypoglycemia and discusses their implications for newborn care. Evidence indicates that all of the major forms of neonatal hypoglycemia are the result of hyperinsulinism due to dysregulation of pancreatic islet insulin secretion. Based on these observations, the authors propose that routine measurement of B-hydroxybutyrate should be considered an essential part of glucose monitoring in newborn infants.
Competing Interests: Disclosure C.A. Stanley serves on the Data Safety Monitoring Board for Zealand Pharma clinical trials in hyperinsulinism. D.D. De Leon has received consulting fees from Zealand Pharma A/S, Crinetics Pharmaceuticals, Hanmi Pharmaceuticals, Eiger Pharma, Twist Biosciences, and Rhythm Pharmaceuticals. Diva D. De Leon has received research funding from Zealand Pharma A/S, Rezolute, Crinetics Pharmaceuticals, Hanmi Pharmaceuticals, Twist Biosciences, Eiger Pharma, and Ultragenyx, United States for studies not discussed in this article. D.D. De Leon and C.A. Stanley serve on the Scientific Advisory Board for Congenital Hyperinsulinism International.
(Copyright © 2024 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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