Vaginal anaerobes are associated with cervicitis: A case-control study.

Autor: Plummer EL; School of Translational Medicine, Monash University, Melbourne, Victoria, Australia; Melbourne Sexual Health Centre, Alfred Hospital, Carlton, Victoria, Australia. Electronic address: erica.plummer@monash.edu., Vodstrcil LA; School of Translational Medicine, Monash University, Melbourne, Victoria, Australia; Melbourne Sexual Health Centre, Alfred Hospital, Carlton, Victoria, Australia; Melbourne School of Population and Global Health, the University of Melbourne, Parkville, Victoria, Australia. Electronic address: lenka.vodstrcil@monash.edu., Danielewski JA; Murdoch Children's Research Institute, Parkville, Australia; Women's Centre for Infectious Diseases, the Royal Women's Hospital, Parkville, Australia; Department of Obstetrics and Gynaecology, the University of Melbourne, Parkville, Australia. Electronic address: Jennifer.danielewski@mcri.edu.au., Murray GL; Murdoch Children's Research Institute, Parkville, Australia; Women's Centre for Infectious Diseases, the Royal Women's Hospital, Parkville, Australia; Department of Obstetrics and Gynaecology, the University of Melbourne, Parkville, Australia. Electronic address: Gerald.murray@mcri.edu.au., Doyle ML; Melbourne Sexual Health Centre, Alfred Hospital, Carlton, Victoria, Australia. Electronic address: michelle.louise.doyle@gmail.com., Latimer RL; School of Translational Medicine, Monash University, Melbourne, Victoria, Australia; Melbourne Sexual Health Centre, Alfred Hospital, Carlton, Victoria, Australia. Electronic address: latimer.rosie@outlook.com., Fairley CK; School of Translational Medicine, Monash University, Melbourne, Victoria, Australia; Melbourne Sexual Health Centre, Alfred Hospital, Carlton, Victoria, Australia. Electronic address: CFairley@mshc.org.au., Chow EPF; School of Translational Medicine, Monash University, Melbourne, Victoria, Australia; Melbourne Sexual Health Centre, Alfred Hospital, Carlton, Victoria, Australia; Melbourne School of Population and Global Health, the University of Melbourne, Parkville, Victoria, Australia. Electronic address: Echow@mshc.org.au., Garland SM; Murdoch Children's Research Institute, Parkville, Australia; Women's Centre for Infectious Diseases, the Royal Women's Hospital, Parkville, Australia; Department of Obstetrics and Gynaecology, the University of Melbourne, Parkville, Australia. Electronic address: suzanne.garland@thewomens.org.au., Bradshaw CS; School of Translational Medicine, Monash University, Melbourne, Victoria, Australia; Melbourne Sexual Health Centre, Alfred Hospital, Carlton, Victoria, Australia; Melbourne School of Population and Global Health, the University of Melbourne, Parkville, Victoria, Australia. Electronic address: catriona.bradshaw@monash.edu.
Jazyk: angličtina
Zdroj: The Journal of infection [J Infect] 2024 Aug; Vol. 89 (2), pp. 106210. Date of Electronic Publication: 2024 Jun 27.
DOI: 10.1016/j.jinf.2024.106210
Abstrakt: Objectives: Cervicitis is associated with important reproductive sequelae. Primary causes include chlamydia and gonorrhoea, but a known sexually transmitted infection (STI) is not identified in >50% of cases (i.e. STI-negative cervicitis). Bacterial vaginosis (BV) and specific BV-associated bacteria have also been associated with cervicitis, but data are limited. We investigated the association between STI-negative cervicitis and vaginal microbiota composition.
Methods: This was a case-control sub-study of the OhMG study conducted at the Melbourne Sexual Health Centre. Cases were women with cervicitis who tested negative for STIs (STI-negative cervicitis, n = 64). Controls were STI-negative asymptomatic women attending for STI-screening (n = 128). The vaginal microbiota was characterised using 16S rRNA gene sequencing. Vaginal community state types were compared between cases and controls using logistic regression. Differential abundance analysis was performed to identify taxa associated with STI-negative cervicitis.
Results: STI-negative cervicitis cases were more likely than controls to have a Lactobacillus-deficient non-optimal microbiota (adjusted-odds-ratio 2.55, 95% CI 1.18-5.50). Compared to controls, cases had increased abundance of four BV-associated bacteria (Gardnerella, Fannyhessea vaginae, Prevotella bivia, Dialister micraerophilus) and decreased abundance of optimal lactobacilli.
Conclusions: We report a positive association between non-optimal vaginal microbiota composition and STI-negative cervicitis. Specific anaerobic BV-associated bacteria may represent infectious causes of cervicitis.
Competing Interests: Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Melbourne Sexual Health Centre received funding from SpeeDx Pty Ltd (Australia) in support of the parent OhMG study. SMG has received consultancy fees from Merck for work unrelated to this manuscript. All other authors report no potential conflict of interest.
(Copyright © 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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