Modeling brain pathology to study nose-to-brain drug delivery.
| Autor: | Talgatkyzy А, Khaibullin T, Syzdykbayev M, Kazymov M, Sharapiyeva A, Amrenova K, Dinara S, Тoktabayeva В, Khamitova M, Apsalikov B, Ozhmukhametova E |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | Bratislavske lekarske listy [Bratisl Lek Listy] 2024; Vol. 125 (7), pp. 435-7440. |
| DOI: | 10.4149/BLL_2024_67 |
| Abstrakt: | Objectives: To create a new mucoadhesive dosage form based on PluronicF127 followed by transformation into a gel form upon intranasal administration for targeted delivery to brain tissueMETHODS: Citicoline, cytidine diphosphocholine, designated as CDP-choline, was purchased as a white powder with the molecular weight of 510.31 g/mol. The triblock copolymers of polyethylene glycol-block-polypropylene glycol-block-polyethylene glycol (PEG-PPG-PEG), branded as Pluronic F127, was used. Results: When instilled into the nasal cavity, Pluronic F127 for intranasal administration is transformed into a gel that remains retained for 45-55 minutes, which promotes better penetration of drugs into the brain tissue. Conclusion: The polymer's gelling and adhesive properties performed well, which is crucial for further research at the preclinical stage (Tab. 1, Fig. 5, Ref. 28). |
| Databáze: | MEDLINE |
| Externí odkaz: |
|