Biosynthesis of Natural and Unnatural Perylenequinones for Drug Development.

Autor: Su Z; Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, 214122, P. R. China., Zhang Y; School of Life Sciences and Health Engineering, Jiangnan University, Wuxi, 214122, P. R. China., Yuan Z; Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, 214122, P. R. China., Rao Y; Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, 214122, P. R. China.
Jazyk: angličtina
Zdroj: ChemMedChem [ChemMedChem] 2024 Oct 16; Vol. 19 (20), pp. e202400295. Date of Electronic Publication: 2024 Aug 20.
DOI: 10.1002/cmdc.202400295
Abstrakt: A wide range of perylenequinones (PQs) with diverse structures and versatile bioactivities have long been isolated, positioning them as highly promising agents for photodynamic therapy (PDT). However, the lack of an efficient and cost-effective method to obtain these compounds and to introduce structural diversity and complexity currently hinders their further research and application. In this concept, we present a comprehensive overview of the advancements in the biosynthetic pathways of natural PQs based on their structural classification, and also summarize recent progress in the biosynthesis of natural PQs and derivatives. These pioneering efforts may pave the way for structure modification and large-scale bioproduction of natural and unnatural PQs through synthetic biology strategies to promote their drug development.
(© 2024 Wiley-VCH GmbH.)
Databáze: MEDLINE
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