Virtual reality application matches the most established treatment for Mal de Debarquement Syndrome: A non-inferiority, randomized, open clinical trial.
| Autor: | Schoenmaekers C; Lab for Equilibrium Investigations and Aerospace, University of Antwerp, Antwerp, Belgium. Electronic address: catho.schoenmaekers@uantwerpen.be., De Smet D; Lab for Equilibrium Investigations and Aerospace, University of Antwerp, Antwerp, Belgium., Deblieck C; Lab for Equilibrium Investigations and Aerospace, University of Antwerp, Antwerp, Belgium., Van Riel J; Telmio BV, Luchthavenlaan 27, Vilvoorde, Belgium., Zarowski A; Telmio BV, Luchthavenlaan 27, Vilvoorde, Belgium; European Institute for ORL-HNS, Sint-Augustinus Hospital, Wilrijk, Belgium., Wuyts FL; Lab for Equilibrium Investigations and Aerospace, University of Antwerp, Antwerp, Belgium; Telmio BV, Luchthavenlaan 27, Vilvoorde, Belgium; European Institute for ORL-HNS, Sint-Augustinus Hospital, Wilrijk, Belgium. |
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| Jazyk: | angličtina |
| Zdroj: | Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics [Neurotherapeutics] 2024 Sep; Vol. 21 (5), pp. e00390. Date of Electronic Publication: 2024 Jun 27. |
| DOI: | 10.1016/j.neurot.2024.e00390 |
| Abstrakt: | Mal de Debarquement Syndrome (MdDS) is a debilitating neuro-otological disorder where individuals consistently feel self-motion, often triggered by motion like being on a boat (MT-MdDS). Due to the unknown pathophysiological mechanism, available treatment options for managing symptoms are limited. Our objective was to develop a virtual reality application (VRA) to simulate the full field optokinetic stimulation (OKS) booth and evaluate its efficacy compared to the standard treatment. In our randomized, open, non-inferiority clinical trial with 30 MT-MdDS patients, 15 received the OKS booth and 15 the new VRA over four consecutive days. Two 4-min treatment blocks were scheduled in the morning and afternoon, with a total of four blocks. Treatment effectiveness was evaluated through questionnaires and posturography. Our findings suggest that the choice of modality does not significantly differ in achieving an overall improvement in symptoms. We advocate that the VRA can be used as an accessible alternative to the booth method worldwide, effectively mitigating MdDS symptoms and enhancing the QoL of numerous MdDS patients. (Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.) |
| Databáze: | MEDLINE |
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