Association of Antibodies to Helminth Defense Molecule 1 With Inflammation, Organomegaly, and Decreased Nutritional Status in Schistosomiasis Japonica.

Autor:	Ruiz AE; Center for International Health Research, Rhode Island Hospital, Brown University Medical School, Providence, Rhode Island, USA.; Department of Pathology and Laboratory Medicine, Brown University Medical School, Providence, Rhode Island, USA., Pond-Tor S; Center for International Health Research, Rhode Island Hospital, Brown University Medical School, Providence, Rhode Island, USA., Stuart R; Center for International Health Research, Rhode Island Hospital, Brown University Medical School, Providence, Rhode Island, USA., Acosta LP; Department of Immunology, Research Institute of Tropical Medicine, Manila, the Philippines., Coutinho HM; Department of Immunology, Research Institute of Tropical Medicine, Manila, the Philippines., Leenstra T; Department of Immunology, Research Institute of Tropical Medicine, Manila, the Philippines.; Department of Pediatrics, Rhode Island Hospital, Brown University Medical School, Providence, Rhode Island, USA., Fisher S; Center for International Health Research, Rhode Island Hospital, Brown University Medical School, Providence, Rhode Island, USA., Fahey O; Center for International Health Research, Rhode Island Hospital, Brown University Medical School, Providence, Rhode Island, USA., McDonald EA; Center for International Health Research, Rhode Island Hospital, Brown University Medical School, Providence, Rhode Island, USA.; Department of Pediatrics, Rhode Island Hospital, Brown University Medical School, Providence, Rhode Island, USA., Jiz MA; Center for International Health Research, Rhode Island Hospital, Brown University Medical School, Providence, Rhode Island, USA.; Department of Pathology and Laboratory Medicine, Brown University Medical School, Providence, Rhode Island, USA.; Department of Immunology, Research Institute of Tropical Medicine, Manila, the Philippines., Olveda RM; Center for International Health Research, Rhode Island Hospital, Brown University Medical School, Providence, Rhode Island, USA., McGarvey ST; Department of Epidemiology and International Health Institute, Brown University School of Public Health, Providence, Rhode Island, USA., Friedman JF; Center for International Health Research, Rhode Island Hospital, Brown University Medical School, Providence, Rhode Island, USA.; Department of Pediatrics, Rhode Island Hospital, Brown University Medical School, Providence, Rhode Island, USA., Wu HW; Center for International Health Research, Rhode Island Hospital, Brown University Medical School, Providence, Rhode Island, USA.; Department of Pediatrics, Rhode Island Hospital, Brown University Medical School, Providence, Rhode Island, USA., Kurtis JD; Center for International Health Research, Rhode Island Hospital, Brown University Medical School, Providence, Rhode Island, USA.; Department of Pathology and Laboratory Medicine, Brown University Medical School, Providence, Rhode Island, USA.
Jazyk:	angličtina
Zdroj:	The Journal of infectious diseases [J Infect Dis] 2024 Oct 16; Vol. 230 (4), pp. 1023-1032.
DOI:	10.1093/infdis/jiae330
Abstrakt:	Immunomodulation enhances parasite fitness by reducing inflammation-induced morbidity in the mammalian host, as well as by attenuating parasite-targeting immune responses. Using a whole-proteome differential screening method, we identified Schistosoma japonicum helminth defense molecule 1 (SjHDM-1) as a target of antibodies expressed by S. japonicum-resistant but not S. japonicum-susceptible individuals. In a longitudinal cohort study (n = 644) conducted in a S. japonicum-endemic region of the Philippines, antibody levels to SjHDM-1 did not predict resistance to reinfection but were associated with increased measures of inflammation. Individuals with high levels of anti-SjHDM-1 immunoglobulin G had higher levels of C-reactive protein than those with low anti-SjHDM-1. High anti-SjHDM-1 immunoglobulin G responses were also associated with reduced biomarkers of nutritional status (albumin), as well as decreased anthropometric measures of nutritional status (weight-for-age and height-for-age z scores) and increased measures of hepatomegaly. Our results suggest that anti-SjHDM-1 responses inhibit the immunomodulatory function of SjHDM-1, resulting in increased morbidity rates. Competing Interests: Potential conflicts of interest. All authors: No reported conflicts. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed. (© The Author(s) 2024. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.)
Databáze:	MEDLINE
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