Sex-specific impact of inflammation on traditional cardiovascular risk factors and atherosclerosis in axial spondyloarthritis. A multicentre study of 913 patients.

Autor:	Ferraz-Amaro I; Servicio de Reumatologia, Hospital Universitario de Canarias, La Laguna, Spain., Genre F; Grupo Inmunopatología, Hospital Marqués de Valdecilla-IDIVAL, Santander, Spain., Blanco R; Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain.; Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain., Calvo-Rio V; Grupo Inmunopatología, Hospital Marqués de Valdecilla-IDIVAL, Santander, Spain.; Reumatologia, Hospital Universitario Marques de Valdecilla, Santander, Spain., Corrales-Selaya C; Grupo Inmunopatología, Hospital Marqués de Valdecilla-IDIVAL, Santander, Spain.; Hospital Universitario Marqués de Valdecilla, Servicio de Reumatología, Santander, Spain., Portilla V; Hospital Universitario Marques de Valdecilla, Santander, Spain., Aurrecoechea E; Rheumatology, Hospital Sierrallana, Torrelavega, Spain., Batanero R; Endocrino, Hospital Universitario Marques de Valdecilla, Santander, Spain., Hernández-Hernández V; Hospital Universitario de Canarias, La Laguna, Spain., Quevedo-Abeledo JC; Hospital Universitario de Gran Canaria Dr Negrín, Las Palmas de Gran Canaria, Spain., Rodríguez-Lozano C; Rheumatology Department, Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, Spain., López-Medina C; Rheumatology, Reina Sofia University Hospital, Cordoba, Spain.; GC05, Maimonides Biomedical Research Institute of Cordoba, Cordoba, Spain., Ladehesa-Pineda L; University of Cordoba, Cordoba, Spain., Castañeda S; Rheumatology Department, Hospital Universitario La Princesa, Madrid, Spain.; Rheumatology, FJD, Madrid, Spain., Vicente-Rabaneda EF; Rheumatology, Hospital de La Princesa, Madrid, Spain., Fernández-Carballido C; Rheumatology, Hospital General Universitario de Elda, Elda, Spain., Martínez Vidal MP; Hospital General Universitario de Alicante, Alicante, Spain., Castro Corredor D; Servicio de Reumatología, Hospital General Universitario de Ciudad Real, Ciudad Real, Spain., Anino Fernández J; Rheumatology Department, Ciudad Real General Hospital, Ciudad Real, Spain., Peiteado D; Hospital Universitario La Paz, Madrid, Spain., Plasencia-Rodriguez C; Rheumatology, Hospital Universitario La Paz, Madrid, Spain., Expósito R; Hospital Universitario Basurto, Bilbao, Spain., Garcia Vivar ML; Department of Rheumatology, Osakidetza Basque Health Service, Basurto University Hospital, Barcelona, Spain., Galíndez-Agirregoikoa E; Reumatologia, Hospital de Basurto, Basurto, Spain., Vegas N; Reumatologia, Hospital de Galdakao-Usansolo, Galdakao, Spain., Urionagüena I; Rheumatology Division, Hospital Universitario Cruces, Barakaldo, Spain., Montes-Perez E; Diagnóstico Médico Cantabria (DMC), Santander, Spain., Gonzalez-Gay MA; Rheumatology, ISS Fundacion Jimenez Diaz, Madrid, Spain miguelaggay@hotmail.com.; Department of Medicine and Psychiatry, Medicine, University of Cantabria, Santander, Spain., Rueda-Gotor J; Grupo Inmunopatología, Hospital Marqués de Valdecilla-IDIVAL, Santander, Spain.; Reumatologia, Hospital Sierrallana y Tres Mares, Torrelavega, Spain.
Jazyk:	angličtina
Zdroj:	RMD open [RMD Open] 2024 Jun 28; Vol. 10 (2). Date of Electronic Publication: 2024 Jun 28.
DOI:	10.1136/rmdopen-2024-004187
Abstrakt:	Introduction: The nature of the relationship between inflammation, cardiovascular (CV) risk factors and atherosclerosis in axial spondyloarthritis (axSpA) remains largely unknown and sex differences in this regard are yet to be assessed. Methods: Study including 611 men and 302 women from the Spanish multicentre AtheSpAin cohort to assess CV disease in axSpA. Data on CV disease risk factors were collected both at disease diagnosis and at enrolment, and data on disease activity, functional indices and carotid ultrasonography only at enrolment. Results: After a median disease duration of 9 years, patients of both sexes who at disease diagnosis had elevated acute phase reactants (APRs), more frequently had hypertension and obesity. The same occurred with dyslipidaemia in men and with diabetes mellitus in women. At enrolment, CV risk factors were independently associated with APR and with activity and functional indices, with various sex differences. C reactive protein (CRP) values were inversely associated with HDL-cholesterol in men (β coefficient: -1.2 (95% CI: -0.3 to -0.07) mg/dL, p=0.001), while erythrocyte sedimentation rate values were positively associated with triglycerides in women (β coefficient: 0.6 (95% CI: 0.04 to 1) mg/dL, p=0.035). Furthermore, only women showed an independent relationship between insulin resistance parameters and APR or disease activity. Both men and women with high-very high CV risk according to the Systematic Assessment of Coronary Risk Evaluation 2 and CRP levels higher than 3 mg/L at diagnosis of the disease presented carotid plaques significantly more frequently than those with normal CRP levels at disease diagnosis. Conclusion: Inflammation is associated with atherosclerosis and CV disease in axSpA. A gender-driven effect is observed in this relationship. Competing Interests: Competing interests: None declared. (© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
Databáze:	MEDLINE
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