Similarities and differences between post-traumatic stress disorder and major depressive disorder: Evidence from task-evoked functional magnetic resonance imaging meta-analysis.

Autor:	Wang Z; Sichuan Provincial Center for Mental Health, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu 610072, China; Key Laboratory of Psychosomatic Medicine, Chinese Academy of Medical Sciences, Chengdu 610072, China., He D; Mental Health Center and Psychiatric Laboratory, West China Hospital of Sichuan University, Chengdu 610041, China; Huaxi Brain Research Center, West China Hospital of Sichuan University, Chengdu 610041, Sichuan, China; Med-X Center for Informatics, Sichuan University, Chengdu 610041, Sichuan, China., Yang L; Mental Health Center and Psychiatric Laboratory, West China Hospital of Sichuan University, Chengdu 610041, China; Huaxi Brain Research Center, West China Hospital of Sichuan University, Chengdu 610041, Sichuan, China; Med-X Center for Informatics, Sichuan University, Chengdu 610041, Sichuan, China., Wang P; Sichuan Provincial Center for Mental Health, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu 610072, China; Key Laboratory of Psychosomatic Medicine, Chinese Academy of Medical Sciences, Chengdu 610072, China., Xiao J; Sichuan Provincial Center for Mental Health, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu 610072, China; Key Laboratory of Psychosomatic Medicine, Chinese Academy of Medical Sciences, Chengdu 610072, China., Zou Z; Sichuan Provincial Center for Mental Health, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu 610072, China; Key Laboratory of Psychosomatic Medicine, Chinese Academy of Medical Sciences, Chengdu 610072, China., Min W; Sichuan Provincial Center for Mental Health, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu 610072, China; Key Laboratory of Psychosomatic Medicine, Chinese Academy of Medical Sciences, Chengdu 610072, China., He Y; Sichuan Provincial Center for Mental Health, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu 610072, China; Key Laboratory of Psychosomatic Medicine, Chinese Academy of Medical Sciences, Chengdu 610072, China., Yuan C; Sichuan Provincial Center for Mental Health, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu 610072, China; Key Laboratory of Psychosomatic Medicine, Chinese Academy of Medical Sciences, Chengdu 610072, China., Zhu H; Mental Health Center and Psychiatric Laboratory, West China Hospital of Sichuan University, Chengdu 610041, China; Huaxi Brain Research Center, West China Hospital of Sichuan University, Chengdu 610041, Sichuan, China; Med-X Center for Informatics, Sichuan University, Chengdu 610041, Sichuan, China. Electronic address: zhuhongru@wchscu.cn., Robinson OJ; Institute of Cognitive Neuroscience, University College London, London, UK; Clinical, Educational and Health Psychology, University College London, London, UK.
Jazyk:	angličtina
Zdroj:	Journal of affective disorders [J Affect Disord] 2024 Sep 15; Vol. 361, pp. 712-719. Date of Electronic Publication: 2024 Jun 26.
DOI:	10.1016/j.jad.2024.06.095
Abstrakt:	Background: Post-traumatic stress disorder (PTSD) and major depressive disorder (MDD) are psychiatric disorders that can present with overlapping symptoms and shared risk factors. However, the extent to which these disorders share common underlying neuropathological mechanisms remains unclear. To investigate the similarities and differences in task-evoked brain activation patterns between patients with PTSD and MDD. Methods: A coordinate-based meta-analysis was conducted across 35 PTSD studies (564 patients and 543 healthy controls) and 125 MDD studies (4049 patients and 4170 healthy controls) using anisotropic effect-size signed differential mapping software. Results: Both PTSD and MDD patients exhibited increased neural activation in the bilateral inferior frontal gyrus. However, PTSD patients showed increased neural activation in the right insula, left supplementary motor area extending to median cingulate gyrus and superior frontal gyrus (SFG), and left fusiform gyrus, and decreased neural activation in the right posterior cingulate gyrus, right middle temporal gyrus, right paracentral lobule, and right inferior parietal gyrus relative to MDD patients. Conclusion: Our meta-analysis suggests that PTSD and MDD share some similar patterns of brain activation, but also have distinct neural signatures. These findings contribute to our understanding of the potential neuropathology underlying these disorders and may inform the development of more targeted and effective treatment and intervention strategies. Moreover, these results may provide useful neuroimaging targets for the differential diagnosis of MDD and PTSD. Competing Interests: Declaration of competing interest OJR held a Medical Research Council Proximity-to-Discovery award with Roche and an investigator-initiated trial with medication donated by Lundbeck, he has completed consultancy work for Peak, Ieso Digital Health, Roche and Blackthorn therapeutics, and sat on the committee of the British Association of Psychopharmacology until 2022. Other authors have no conflict of interest to declare. (Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze:	MEDLINE
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