Validation and reproducibility of in vivo dosimetry for pencil beam scanned FLASH proton treatment in mice.

Autor: Bookbinder A; New York Proton Center, New York, NY, USA., Selvaraj B; New York Proton Center, New York, NY, USA., Zhao X; New York Proton Center, New York, NY, USA., Yang Y; New York Proton Center, New York, NY, USA; Departments of Radiation Oncology and Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Bell BI; Department of Radiation Oncology, Montefiore Medical Center and Albert Einstein College of Medicine, Bronx, NY, USA; Department of Pathology, Albert Einstein College of Medicine, Bronx, NY, USA., Pennock M; Department of Radiation Oncology, Montefiore Medical Center and Albert Einstein College of Medicine, Bronx, NY, USA., Tsai P; New York Proton Center, New York, NY, USA; Departments of Radiation Oncology and Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Tomé WA; Department of Radiation Oncology, Montefiore Medical Center and Albert Einstein College of Medicine, Bronx, NY, USA; Institute for Onco-Physics, Albert Einstein College of Medicine, Bronx, NY, USA., Isabelle Choi J; New York Proton Center, New York, NY, USA; Departments of Radiation Oncology and Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Lin H; New York Proton Center, New York, NY, USA; Departments of Radiation Oncology and Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Department of Radiation Oncology, Montefiore Medical Center and Albert Einstein College of Medicine, Bronx, NY, USA., Simone CB 2nd; New York Proton Center, New York, NY, USA; Departments of Radiation Oncology and Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Guha C; Department of Radiation Oncology, Montefiore Medical Center and Albert Einstein College of Medicine, Bronx, NY, USA; Department of Pathology, Albert Einstein College of Medicine, Bronx, NY, USA; Institute for Onco-Physics, Albert Einstein College of Medicine, Bronx, NY, USA., Kang M; New York Proton Center, New York, NY, USA; Departments of Radiation Oncology and Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Electronic address: mkang@nyproton.com.
Jazyk: angličtina
Zdroj: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology [Radiother Oncol] 2024 Sep; Vol. 198, pp. 110404. Date of Electronic Publication: 2024 Jun 26.
DOI: 10.1016/j.radonc.2024.110404
Abstrakt: Purpose: To investigate quality assurance (QA) techniques for in vivo dosimetry and establish its routine uses for proton FLASH small animal experiments with a saturated monitor chamber.
Methods and Materials: 227 mice were irradiated at FLASH or conventional (CONV) dose rates with a 250 MeV FLASH-capable proton beamline using pencil beam scanning to characterize the proton FLASH effect on abdominal irradiation and examining various endpoints. A 2D strip ionization chamber array (SICA) detector was positioned upstream of collimation and used for in vivo dose monitoring during irradiation. Before each irradiation series, SICA signal was correlated with the isocenter dose at each delivered dose rate. Dose, dose rate, and 2D dose distribution for each mouse were monitored with the SICA detector.
Results: Calibration curves between the upstream SICA detector signal and the delivered dose at isocenter had good linearity with minimal R 2 values of 0.991 (FLASH) and 0.985 (CONV), and slopes were consistent for each modality. After reassigning mice, standard deviations were less than 1.85 % (FLASH) and 0.83 % (CONV) for all dose levels, with no individual subject dose falling outside a ± 3.6 % range of the designated dose. FLASH fields had a field-averaged dose rate of 79.0 ± 0.8 Gy/s and mean local average dose rate of 160.6 ± 3.0 Gy/s. In vivo dosimetry allowed for the accurate detection of variation between the delivered and the planned dose.
Conclusion: In vivo dosimetry benefits FLASH experiments through enabling real-time dose and dose rate monitoring allowing mouse cohort regrouping when beam fluctuation causes delivered dose to vary from planned dose.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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