The combined effect of morin and hesperidin on memory ability and oxidative/nitrosative stress in a streptozotocin-induced rat model of Alzheimer's disease.

Autor: Yilmazer UT; Department of Biology, Faculty of Science, Gazi University, Ankara, Turkey., Pehlivan B; Department of Biology, Faculty of Science, Gazi University, Ankara, Turkey., Guney S; Department of Physiology, Faculty of Medicine, Gazi University, Ankara, Turkey., Yar-Saglam AS; Department of Medical Biology and Genetics, Faculty of Medicine, Gazi University, Ankara, Turkey., Balabanli B; Department of Biology, Faculty of Science, Gazi University, Ankara, Turkey., Kaltalioglu K; Espiye Vocational School, Giresun University, Giresun, Turkey., Coskun-Cevher S; Department of Biology, Faculty of Science, Gazi University, Ankara, Turkey. Electronic address: sule@gazi.edu.tr.
Jazyk: angličtina
Zdroj: Behavioural brain research [Behav Brain Res] 2024 Aug 05; Vol. 471, pp. 115131. Date of Electronic Publication: 2024 Jun 26.
DOI: 10.1016/j.bbr.2024.115131
Abstrakt: Alzheimer's disease (AD), the most frequent neurodegenerative disease within dementias, affects the CNS, leading to gradual memory issues and cognitive dysfunction. Oxidative stress in AD contributes to ongoing neuronal loss and hastens disease progression. Notably, the potent antioxidant compounds morin and hesperidin have demonstrated significant effectiveness in addressing oxidative stress. This study explores the impact of morin and hesperidin on behavior and oxidative stress in the streptozotocin (STZ)-induced AD rat model. The experiment involved five groups: control, STZ, STZ+morin, STZ+hesperidin, and STZ+morin+hesperidin. The rat model of AD was created by injecting STZ with the stereotaxic surgery. Morin and hesperidin were applied to the groups for 7-days. After the applications, the Morris water maze (MWM) and novel object recognition (NOR) tests were used and the rats were sacrificed. Malondialdehyde (MDA), glutathione (GSH), nitric oxide (NOx), and protein carbonyl (PC) levels were measured. In the STZ group, the levels of NOx and PC exhibited a noteworthy increase compared to the control. Conversely, the application of morin and/or hesperidin treatments reduced NOx and PC levels compared to the STZ group. The co-administration of morin and hesperidin improved the antioxidant status and decreased lipid peroxidation in STZ-induced rats. In the STZ group, serum advanced oxidation protein products (AOPP) levels were statistically elevated compared to the control. However, in the treatment groups, morin and/or hesperidin successfully decreased AOPP levels to those observed in the control. The combined use of these flavonoids may have a neuroprotective effect regarding memory problems and decreasing oxidative/nitrosative stress.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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