Development and characterization of the mode-of-action of inhibitory and agonist peptides targeting the voltage-gated sodium channel SCN1B beta-subunit.
Autor: | Williams ZJ; Fralin Biomedical Research Institute, Virginia Polytechnic University, Roanoke, VA, United States., Alvarez-Laviada A; Department of Myocardial Function, Imperial College London, London, United Kingdom., Hoagland D; Fralin Biomedical Research Institute, Virginia Polytechnic University, Roanoke, VA, United States., Jourdan LJ; Fralin Biomedical Research Institute, Virginia Polytechnic University, Roanoke, VA, United States., Poelzing S; Fralin Biomedical Research Institute, Virginia Polytechnic University, Roanoke, VA, United States; School of Medicine, Virgina Polytechnic University, Roanoke, VA, United States; Department of Biomedical Engineering and Mechanics, Virginia Polytechnic University, Roanoke, VA, United States., Gorelik J; Department of Myocardial Function, Imperial College London, London, United Kingdom., Gourdie RG; Fralin Biomedical Research Institute, Virginia Polytechnic University, Roanoke, VA, United States; School of Medicine, Virgina Polytechnic University, Roanoke, VA, United States; Department of Biomedical Engineering and Mechanics, Virginia Polytechnic University, Roanoke, VA, United States. Electronic address: gourdier@vtc.vt.edu. |
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Jazyk: | angličtina |
Zdroj: | Journal of molecular and cellular cardiology [J Mol Cell Cardiol] 2024 Sep; Vol. 194, pp. 32-45. Date of Electronic Publication: 2024 Jun 26. |
DOI: | 10.1016/j.yjmcc.2024.06.008 |
Abstrakt: | Cardiac arrhythmia treatment is a clinical challenge necessitating safer and more effective therapies. Recent studies have highlighted the role of the perinexus, an intercalated disc nanodomain enriched in voltage-gated sodium channels including both Na Competing Interests: Declaration of competing interest Authors Zachary J. Williams, Daniel Hoagland, L. Jane Jourdan, Steven Poelzing, and Robert G. Gourdie report a PCT patent application submitted to USPTO Mar. 1st 2023 (PCT/US2023/063525) on the β1 mimetic dimeric peptides that are the subject of this manuscript. (Copyright © 2024. Published by Elsevier Ltd.) |
Databáze: | MEDLINE |
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