Evolutionary and biomedical implications of sex differences in the primate brain transcriptome.

Autor:	DeCasien AR; Department of Anthropology, New York University, New York, NY, USA; New York Consortium in Evolutionary Primatology, New York, NY, USA; Section on Developmental Neurogenomics, National Institute of Mental Health, Bethesda, MD, USA. Electronic address: alex.decasien@gmail.com., Chiou KL; Center for Evolution and Medicine, Arizona State University, Tempe, AZ, USA; School of Life Sciences, Arizona State University, Tempe, AZ, USA; Department of Psychology, University of Washington, Seattle, WA, USA; Nathan Shock Center of Excellence in the Basic Biology of Aging, University of Washington, Seattle, WA, USA. Electronic address: kenny.chiou@gmail.com., Testard C; Department of Neuroscience, University of Pennsylvania, Philadelphia, PA, USA., Mercer A; Department of Psychology, University of Washington, Seattle, WA, USA., Negrón-Del Valle JE; School of Life Sciences, Arizona State University, Tempe, AZ, USA., Bauman Surratt SE; Caribbean Primate Research Center, University of Puerto Rico, San Juan, PR, USA., González O; Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX, USA., Stock MK; Department of Sociology and Anthropology, Metropolitan State University of Denver, Denver, CO, USA., Ruiz-Lambides AV; Caribbean Primate Research Center, University of Puerto Rico, San Juan, PR, USA., Martínez MI; Caribbean Primate Research Center, University of Puerto Rico, San Juan, PR, USA., Antón SC; Department of Anthropology, New York University, New York, NY, USA; New York Consortium in Evolutionary Primatology, New York, NY, USA., Walker CS; Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA., Sallet J; Stem Cell and Brain Research Institute, Université Lyon, Lyon, France., Wilson MA; Center for Evolution and Medicine, Arizona State University, Tempe, AZ, USA; School of Life Sciences, Arizona State University, Tempe, AZ, USA; Biodesign Center for Mechanisms of Evolution, Arizona State University, Tempe, AZ, USA., Brent LJN; Centre for Research in Animal Behavior, University of Exeter, Exeter, UK., Montague MJ; Department of Neuroscience, University of Pennsylvania, Philadelphia, PA, USA., Sherwood CC; Department of Anthropology, The George Washington University, Washington, DC, USA., Platt ML; Department of Neuroscience, University of Pennsylvania, Philadelphia, PA, USA; Department of Psychology, University of Pennsylvania, Philadelphia, PA, USA; Department of Marketing, University of Pennsylvania, Philadelphia, PA, USA., Higham JP; Department of Anthropology, New York University, New York, NY, USA; New York Consortium in Evolutionary Primatology, New York, NY, USA. Electronic address: jhigham@nyu.edu., Snyder-Mackler N; Center for Evolution and Medicine, Arizona State University, Tempe, AZ, USA; School of Life Sciences, Arizona State University, Tempe, AZ, USA; Department of Psychology, University of Washington, Seattle, WA, USA; Nathan Shock Center of Excellence in the Basic Biology of Aging, University of Washington, Seattle, WA, USA; ASU-Banner Neurodegenerative Disease Research Center, Arizona State University, Tempe, AZ, USA. Electronic address: nsnyderm@asu.edu.
Jazyk:	angličtina
Zdroj:	Cell genomics [Cell Genom] 2024 Jul 10; Vol. 4 (7), pp. 100589. Date of Electronic Publication: 2024 Jun 27.
DOI:	10.1016/j.xgen.2024.100589
Abstrakt:	Humans exhibit sex differences in the prevalence of many neurodevelopmental disorders and neurodegenerative diseases. Here, we generated one of the largest multi-brain-region bulk transcriptional datasets for the rhesus macaque and characterized sex-biased gene expression patterns to investigate the translatability of this species for sex-biased neurological conditions. We identify patterns similar to those in humans, which are associated with overlapping regulatory mechanisms, biological processes, and genes implicated in sex-biased human disorders, including autism. We also show that sex-biased genes exhibit greater genetic variance for expression and more tissue-specific expression patterns, which may facilitate rapid evolution of sex-biased genes. Our findings provide insights into the biological mechanisms underlying sex-biased disease and support the rhesus macaque model for the translational study of these conditions. Competing Interests: Declaration of interests The authors declare no competing interests. (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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