Expression of SUMO and NF-κB genes in hepatitis B virus-associated hepatocellular carcinoma patients: An observational study.

Autor:	Khai NX; 103 Military Hospital, Vietnam Military Medical University, Hanoi, Vietnam.; Department of Pathophysiology, Vietnam Military Medical University, Hanoi, Vietnam., Huy DQ; 103 Military Hospital, Vietnam Military Medical University, Hanoi, Vietnam., Trang DT; Institute of Genome Research, Vietnam Academy of Science and Technology, Hanoi, Vietnam., Minh NT; 103 Military Hospital, Vietnam Military Medical University, Hanoi, Vietnam., Tien TD; 103 Military Hospital, Vietnam Military Medical University, Hanoi, Vietnam., Phuong NV; 103 Military Hospital, Vietnam Military Medical University, Hanoi, Vietnam., Dung NV; 108 Military Central Hospital, Hanoi, Vietnam., Hang NT; Department of Pathophysiology, Vietnam Military Medical University, Hanoi, Vietnam., Khanh LV; Institute of Biomedicine and Pharmacy, Vietnam Military Medical University, Hanoi, Vietnam., Hoang NH; Institute of Genome Research, Vietnam Academy of Science and Technology, Hanoi, Vietnam., Xuan NT; Institute of Genome Research, Vietnam Academy of Science and Technology, Hanoi, Vietnam., Mao CV; Department of Pathophysiology, Vietnam Military Medical University, Hanoi, Vietnam., Tong HV; Department of Pathophysiology, Vietnam Military Medical University, Hanoi, Vietnam.; Institute of Biomedicine and Pharmacy, Vietnam Military Medical University, Hanoi, Vietnam.
Jazyk:	angličtina
Zdroj:	Medicine [Medicine (Baltimore)] 2024 Jun 28; Vol. 103 (26), pp. e38737.
DOI:	10.1097/MD.0000000000038737
Abstrakt:	Alterations in signaling pathways and modulation of cell metabolism are associated with the pathogenesis of cancers, including hepatocellular carcinoma (HCC). Small ubiquitin-like modifier (SUMO) proteins and NF-κB family play major roles in various cellular processes. The current study aims to determine the expression profile of SUMO and NF-κB genes in HCC tumors and investigate their association with the clinical outcome of HCC. The expression of 5 genes - SUMO1, SUMO2, SUMO3, NF-κB p65, and NF-κB p50 - was quantified in tumor and adjacent non-tumor tissues of 58 HBV-related HCC patients by real-time quantitative PCR and was analyzed for the possible association with clinical parameters of HCC. The expression of SUMO2 was significantly higher in HCC tumor tissues compared to the adjacent non-tumor tissues (P = .01), while no significant difference in SUMO1, SUMO3, NF-κB p65, and NF-κB p50 expression was observed between HCC tumor and non-tumor tissues (P > .05). In HCC tissues, a strong correlation was observed between the expression of SUMO2 and NF-κB p50, between SUMO3 and NF-κB p50, between SUMO3 and NF-κB p65 (Spearman rho = 0.83; 0.82; 0.772 respectively; P < .001). The expression of SUMO1, SUMO2, SUMO3, NF-κB p65, and NF-κB p50 was decreased in grade 3 compared to grades 1 and 2 in HCC tumors according to the World Health Organization grades system. Our results highlighted that the SUMO2 gene is upregulated in tumor tissues of patients with HCC, and is related to the development of HCC, thus it may be associated with the pathogenesis of HCC. Competing Interests: The authors have no conflicts of interest to disclose. (Copyright © 2024 the Author(s). Published by Wolters Kluwer Health, Inc.)
Databáze:	MEDLINE
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