Validation of the COmprehensive Score for Financial Toxicity (COST) in Vietnamese patients with cancer.

Autor: Tran BT; Faculty of Public Health, University of Medicine and Pharmacy, Hue University, Hue City, Thua Thien Hue Province, Vietnam., Le DD; Faculty of Public Health, University of Medicine and Pharmacy, Hue University, Hue City, Thua Thien Hue Province, Vietnam., Nguyen TG; Faculty of Public Health, University of Medicine and Pharmacy, Hue University, Hue City, Thua Thien Hue Province, Vietnam., Nguyen MT; Undergraduate Training Office, University of Medicine and Pharmacy, Hue University, Hue City, Thua Thien Hue Province, Vietnam., Nguyen MH; Oncology Centre, Hue Central Hospital, Hue City, Thua Thien Hue Province, Vietnam., Dang CK; Faculty of Public Health, University of Medicine and Pharmacy, Hue University, Hue City, Thua Thien Hue Province, Vietnam., Tran DT; Faculty of Public Health, University of Medicine and Pharmacy, Hue University, Hue City, Thua Thien Hue Province, Vietnam.; Faculty of Public Health, Da Nang University of Medical Technology and Pharmacy, Da Nang City, Vietnam.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2024 Jun 28; Vol. 19 (6), pp. e0306339. Date of Electronic Publication: 2024 Jun 28 (Print Publication: 2024).
DOI: 10.1371/journal.pone.0306339
Abstrakt: Introduction: The COmprehensive Score for Financial Toxicity (COST) has proven to be a reliable tool for quantifying the impact of financial toxicity (FT) in patients with cancer in clinical and public health settings. However, the COST has not yet been validated in Vietnam. Therefore, we aimed to evaluate its reliability and validity among Vietnamese patients with cancer.
Methods: A cross-sectional study was conducted in a sample of 300 patients with cancer aged 27-95 years (mean: 58.5±11.2) in a tertiary hospital. The COST was translated into Vietnamese and English and adjusted to suit the local culture. Reliability was evaluated using Cronbach's alpha and McDonald's omega coefficients. The construct and convergent validities were also assessed.
Results: The COST demonstrated good internal consistency and reliability (Cronbach's alpha = 0.913; McDonald's omega = 0.915). The exploratory factor analysis revealed two factors that explained 64.9% of the variance. The adjusted fit indices indicated a good fit of the model (χ2 (39) = 67.78, p = 0.003; standardized root mean squared residual = 0.042; Tucker-Lewis index = 0.971; comparative fit index = 0.979; root mean square error of approximation = 0.061, 90% confidence interval = 0.035-0084). Higher COST scores were significantly correlated with higher health-related quality of life (EQ-5D-5L utility score: r = 0.21, p = 0.002; EQ VAS: r = 0.28, p < 0.001). Multivariate quantile regression analysis revealed that female sex, rural residence, and unstable job/unemployment were associated with lower COST scores. There was no statistically significant difference in other factors, including clinical factors (types of cancer, staging, and treatment modalities).
Conclusions: The COST is reliable and valid, making it suitable for assessing FT severity in Vietnamese patients with cancer.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright: © 2024 Tran et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Databáze: MEDLINE
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