Target Organs of Metals Released from Metal-on-Polyethylene Knee and Hip Arthroplasty Implants: Implications for Tissue Metal Profiles.

Autor: Bellouard M; Department of Pharmacology and Toxicology, AP-HP, Raymond Poincaré Hospital, GHU AP-HP. Paris-Saclay, Garches, 92380, France. marie.martin@aphp.fr.; Saclay/Versailles University, CESP, Team MOODS, U-1018, Plateform MasSpecLab, 78180, Montigny-Le-Bretonneux, France. marie.martin@aphp.fr.; Laboratoire de Toxicologie, Hôpital Raymond Poincaré, 104 Bvd Raymond Poincaré, Garches, 92380, France. marie.martin@aphp.fr., de la GrandMaison GL; Department of Forensic Medicine and Pathology, AP-HP, Raymond Poincaré Hospital, Garches, 92380, France., Rambaud C; Department of Forensic Medicine and Pathology, AP-HP, Raymond Poincaré Hospital, Garches, 92380, France., Marmorat JL; Department of Traumatology and Orthopaedic Surgery, AP-HP, Raymond Poincaré Hospital, Garches, 92380, France., Grimaldi L; AP-HP, Ambroise Paré Hospital, Paris Ouest Research Clinic Unit, Boulogne-Billancourt, 92100, France., Nkam L; AP-HP, Ambroise Paré Hospital, Paris Ouest Research Clinic Unit, Boulogne-Billancourt, 92100, France., Larabi IA; Department of Pharmacology and Toxicology, AP-HP, Raymond Poincaré Hospital, GHU AP-HP. Paris-Saclay, Garches, 92380, France.; Saclay/Versailles University, CESP, Team MOODS, U-1018, Plateform MasSpecLab, 78180, Montigny-Le-Bretonneux, France., Alvarez JC; Department of Pharmacology and Toxicology, AP-HP, Raymond Poincaré Hospital, GHU AP-HP. Paris-Saclay, Garches, 92380, France.; Saclay/Versailles University, CESP, Team MOODS, U-1018, Plateform MasSpecLab, 78180, Montigny-Le-Bretonneux, France.
Jazyk: angličtina
Zdroj: Biological trace element research [Biol Trace Elem Res] 2024 Jun 28. Date of Electronic Publication: 2024 Jun 28.
DOI: 10.1007/s12011-024-04278-2
Abstrakt: Metals are used in orthopedic implants. The wear of arthroplasty implant can lead to the release of arthroprosthetic metals, both locally and systemically, after migration into the organs. While the toxicity of metal-on-metal arthroplasty implants is well-known and monitored, the toxicity associated with metal-on-polyethylene (MoP) ones is not as comprehensively understood. This study aimed to investigate the release of metals from MoP arthroplasty implants and their impact on the tissue metal profile in autopsied individuals, comparing them to deceased controls without prostheses. High-resolution ICP-MS was employed to analyze 39 metals in the blood, urine, hair, organs, and periprosthetic tissue of 25 deceased individuals with arthroplasty implants and 20 control subjects (Prometox study, protocol ID: APHP180539, NCT03812627). Eight metals (beryllium, chromium, cobalt, lanthanum, molybdenum, nickel, tellurium, titanium) exhibited significant impacts in arthroplasty implant wearers across various organs. Increased concentrations of La and Be were observed, the origin of which could not be precisely defined within the scope of this study. Notably, the lungs emerged as the primary target organ for metallic ions contained in implants. This study suggests that MoP arthroplasty implants, even when functional and not visibly worn, release arthroprosthetic metals into the body, potentially causing disturbances. Furthermore, considering the presence of an arthroplasty implant in autopsy reports may be relevant, as the released metals could influence the tissue metal profile.
(© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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