Mechanism of Reactive Oxygen/Nitrogen Species in Liver Ischemia-Reperfusion Injury and Preventive Effect of Chinese Medicine.

Autor: Gao L; School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515, China., Li YJ; The First Affiliated Hospital/the First Clinical Medicine School of Guangdong Pharmaceutical University, Guangzhou, 510006, China., Zhao JM; School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515, China., Liao YX; School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515, China., Qin MC; School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515, China., Li JJ; School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515, China., Shi H; School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515, China., Wong NK; State Key Discipline of Infectious Diseases, Shenzhen Third People's Hospital, the Second Affiliated Hospital, Shenzhen University, Shenzhen, Guangdong Province, 518112, China., Lyu ZP; School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515, China., Shen JG; School of Chinese Medicine, the University of Hong Kong, Hong Kong SAR, China. shenjg@hku.hk.
Jazyk: angličtina
Zdroj: Chinese journal of integrative medicine [Chin J Integr Med] 2024 Jun 28. Date of Electronic Publication: 2024 Jun 28.
DOI: 10.1007/s11655-024-3810-9
Abstrakt: Liver ischemia-reperfusion injury (LIRI) is a pathological process involving multiple injury factors and cell types, with different stages. Currently, protective drugs targeting a single condition are limited in efficacy, and interventions on immune cells will also be accompanied by a series of side effects. In the current bottleneck research stage, the multi-target and obvious clinical efficacy of Chinese medicine (CM) is expected to become a breakthrough point in the research and development of new drugs. In this review, we summarize the roles of reactive oxygen species (ROS) and reactive nitrogen species (RNS) in various stages of hepatic ischemia-reperfusion and on various types of cells. Combined with the current research progress in reducing ROS/RNS with CM, new therapies and mechanisms for the treatment of hepatic ischemia-reperfusion are discussed.
(© 2024. The Chinese Journal of Integrated Traditional and Western Medicine Press and Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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