Sex and Race-Ethnic Disparities in Metabolic Dysfunction-Associated Steatotic Liver Disease: An Analysis of 40,166 Individuals.

Autor: Fu CE; Yong Loo Lin School of Medicine, National University of Singapore, Singapore 10 Medical Dr, Singapore, 117597, Singapore., Teng M; Division of Gastroenterology and Hepatology, Department of Medicine, National University Hospital, Singapore, Singapore., Tung D; Division of Gastroenterology and Hepatology, Department of Medicine, National University Hospital, Singapore, Singapore., Ramadoss V; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Ong C; Yong Loo Lin School of Medicine, National University of Singapore, Singapore 10 Medical Dr, Singapore, 117597, Singapore., Koh B; Yong Loo Lin School of Medicine, National University of Singapore, Singapore 10 Medical Dr, Singapore, 117597, Singapore., Lim WH; Yong Loo Lin School of Medicine, National University of Singapore, Singapore 10 Medical Dr, Singapore, 117597, Singapore., Tan DJH; Yong Loo Lin School of Medicine, National University of Singapore, Singapore 10 Medical Dr, Singapore, 117597, Singapore., Koh JH; Yong Loo Lin School of Medicine, National University of Singapore, Singapore 10 Medical Dr, Singapore, 117597, Singapore.; Division of Gastroenterology and Hepatology, Department of Medicine, National University Hospital, Singapore, Singapore., Nah B; Division of Gastroenterology and Hepatology, Department of Medicine, National University Hospital, Singapore, Singapore., Syn N; Yong Loo Lin School of Medicine, National University of Singapore, Singapore 10 Medical Dr, Singapore, 117597, Singapore.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; National University Centre for Organ Transplantation, National University Health System, Singapore, Singapore., Tamaki N; Department of Gastroenterology and Hepatology, Musashino Red Cross Hospital, Tokyo, Japan., Siddiqui MS; Division of Gastroenterology, Hepatology and Nutrition, Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA, USA., Wijarnpreecha K; Division of Gastroenterology and Hepatology, University of Arizona College of Medicine Phoenix, Phoenix, AZ, USA., Ioannou GN; Division of Gastroenterology, Veterans Affairs Puget Sound Health Care System and University of Washington, Seattle, WA, USA., Nakajima A; Department of Gastroenterology and Hepatology, Yokohama City University Graduate School of Medicine, Kanagawa, Japan., Noureddin M; Houston Research Institute, Houston Methodist Hospital, Houston, USA., Sanyal AJ; Department of Internal Medicine, Stravitz-Sanyal Institute of Liver Disease and Metabolic Health,, Virginia Commonwealth University School of Medicine, Richmond, VA, USA., Ng CH; Yong Loo Lin School of Medicine, National University of Singapore, Singapore 10 Medical Dr, Singapore, 117597, Singapore. chenhanng@gmail.com.; Ministry of Health Holdings, Singapore, Singapore. chenhanng@gmail.com.; Department of Medicine, Kurume University School of Medicine, Kurume, Japan. chenhanng@gmail.com., Muthiah M; Yong Loo Lin School of Medicine, National University of Singapore, Singapore 10 Medical Dr, Singapore, 117597, Singapore.; Division of Gastroenterology and Hepatology, Department of Medicine, National University Hospital, Singapore, Singapore.; National University Centre for Organ Transplantation, National University Health System, Singapore, Singapore.
Jazyk: angličtina
Zdroj: Digestive diseases and sciences [Dig Dis Sci] 2024 Sep; Vol. 69 (9), pp. 3195-3205. Date of Electronic Publication: 2024 Jun 28.
DOI: 10.1007/s10620-024-08540-4
Abstrakt: Background: To overcome the limitations of the term "non-alcoholic fatty liver disease" (NAFLD), the term metabolic-associated steatotic liver disease (MASLD) was introduced. While epidemiologic studies have been conducted on MASLD, there is limited evidence on its associated sex and ethnic variations.
Aims: This study assesses the differences across sex and race-ethnicity on the prevalence, associated risk factors and adverse outcomes in individuals with MASLD.
Methods: Data retrieved from the National Health and Nutrition Examination Survey between 1999 to 2018 was analyzed. Prevalence, clinical characteristics, and outcomes were evaluated according to sex and race-ethnicity. Adverse outcomes and mortality events were analyzed using multivariate analyses.
Results: Of 40,166 individuals included, 37.63% had MASLD. There was a significant increase in MASLD prevalence from 1999 to 2018 among Mexican Americans (Annual Percentage Change [APC] + 1.889%, p < 0.001), other Hispanics (APC + 1.661%, p = 0.013), NH Whites (APC + 1.084%, p = 0.018), NH Blacks (APC + 1.108%, p = 0.007), and females (APC + 0.879%, p = 0.030), but not males. Females with MASLD were at lower risk of all-cause (HR: 0.766, 95%CI 0.711 to 0.825, p < 0.001), cardiovascular disease-related (CVD) (SHR: 0.802, 95% CI 0.698 to 0.922, p = 0.002) and cancer-related mortality (SHR: 0.760, 95% CI 0.662 to 0.873, p < 0.001). Significantly, NH Blacks have the highest risk of all-cause and CVD-related mortality followed by NH Whites then Mexican Americans.
Conclusion: There has been an increase in prevalence in most race-ethnicities over time. While the change in definition shows no significant differences in previous associations found in NAFLD, the increased mortality in NH Whites relative to Mexican Americans remains to be explored.
(© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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