Women and lipoprotein apheresis: another side of gender medicine.

Autor: Dal Pino B; Lipoapheresis Unit - Reference Center for Diagnosis and Treatment of Inherited Dyslipidemias, Fondazione Toscana 'Gabriele Monasterio', Via Moruzzi 1, Pisa, 56124, Italy., Sbrana F; Lipoapheresis Unit - Reference Center for Diagnosis and Treatment of Inherited Dyslipidemias, Fondazione Toscana 'Gabriele Monasterio', Via Moruzzi 1, Pisa, 56124, Italy. francesco.sbrana@ftgm.it.
Jazyk: angličtina
Zdroj: Endocrine [Endocrine] 2024 Dec; Vol. 86 (3), pp. 954-958. Date of Electronic Publication: 2024 Jun 28.
DOI: 10.1007/s12020-024-03941-x
Abstrakt: Aim: In heterozygous Familial Hypercholesterolemia (FH) woman atherosclerotic cardiovascular disease occurs 20-years earlier respect woman without FH while homozygous FH women may suffer from atherosclerotic cardiovascular disease even in childhood. Lipoprotein apheresis, a therapeutic "last chance saloon", is a well-tolerated procedure that markedly lowers LDL-cholesterol and Lp(a) levels in patients who do not achieve acceptable levels with maximal lifestyle and drug therapy.
Methods and Results: The experience of LA treatment in 3 female homozygous FH patients was described. Moreover, an explore analysis on pre and post-LA hormonal levels was performed in 8 HeFH women showing a significant improvement in the atherogenic lipid profile (total cholesterol -56%, LDL cholesterol -71%, triglycerides -72%, Apo B lipoprotein -69%, Lp(a) -59%;) and a reduction of FSH and LH values (FSH - 28%, LH -31%).
Conclusions: Women with FH experience specific barriers to care, including underrepresentation in research, significant underestimation of risk, and discontinuation of therapy during pregnancy. Therefore, in this study, we investigated the possible effects of LA treatment on plasma FSH and LH levels.
Competing Interests: Compliance with ethical standards Ethical approval Ethical approval was waived by the local Ethics Committee in view of the fact that all the procedures being performed were part of the routine care. Informed consent Written informed consent was obtained. Conflict of interest The authors declare no competing interests.
(© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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