Medical Comorbidities, Nutritional Markers, and Cardiovascular Risk Markers in Youth With ARFID.

Autor: Burton-Murray H; Harvard Medical School, Boston, Massachusetts, USA.; Center for Neurointestinal Health, Division of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts, USA.; Mass General Brigham Eating Disorders Research Collaborative, Boston, Massachusetts, USA., Sella AC; The Jesse Z. and Sara Lea Shafer Institute of Endocrinology and Diabetes, National Center for Childhood Diabetes, Schneider Children's Medical Center of Israel, Petah Tikva, Israel.; Neuroendocrine Unit, Division of Endocrinology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA., Gydus JE; Neuroendocrine Unit, Division of Endocrinology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.; Eating Disorders Clinical and Research Program, Massachusetts General Hospital, Boston, Massachusetts, USA., Atkins M; Harvard Medical School, Boston, Massachusetts, USA.; Center for Neurointestinal Health, Division of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts, USA., Palmer LP; Eating Disorders Clinical and Research Program, Massachusetts General Hospital, Boston, Massachusetts, USA., Kuhnle MC; Neuroendocrine Unit, Division of Endocrinology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.; Eating Disorders Clinical and Research Program, Massachusetts General Hospital, Boston, Massachusetts, USA., Becker KR; Harvard Medical School, Boston, Massachusetts, USA.; Mass General Brigham Eating Disorders Research Collaborative, Boston, Massachusetts, USA.; Eating Disorders Clinical and Research Program, Massachusetts General Hospital, Boston, Massachusetts, USA., Breithaupt LE; Harvard Medical School, Boston, Massachusetts, USA.; Mass General Brigham Eating Disorders Research Collaborative, Boston, Massachusetts, USA.; Eating Disorders Clinical and Research Program, Massachusetts General Hospital, Boston, Massachusetts, USA.; Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts, USA., Brigham KS; Harvard Medical School, Boston, Massachusetts, USA.; Mass General Brigham Eating Disorders Research Collaborative, Boston, Massachusetts, USA.; Division of Adolescent and Young Adult Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA., Aulinas A; Department of Endocrinology and Nutrition, Hospital de la Santa Creu i Sant Pau, IR-SANTPAU, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER Unidad 747), ISCIII, Barcelona, Spain.; Department of Medicine, University of Vic - Central University of Catalonia, Barcelona, Spain., Staller K; Harvard Medical School, Boston, Massachusetts, USA.; Center for Neurointestinal Health, Division of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts, USA., Eddy KT; Harvard Medical School, Boston, Massachusetts, USA.; Mass General Brigham Eating Disorders Research Collaborative, Boston, Massachusetts, USA.; Eating Disorders Clinical and Research Program, Massachusetts General Hospital, Boston, Massachusetts, USA., Misra M; Harvard Medical School, Boston, Massachusetts, USA.; Mass General Brigham Eating Disorders Research Collaborative, Boston, Massachusetts, USA.; Division of Pediatric Endocrinology, Massachusetts General Hospital, Boston, Massachusetts, USA., Micali N; Great Ormond Street Institute of Child Health, University College London, London, UK.; Center for Eating and Feeding Disorders Research, Psychiatric Centre Ballerup, Mental Health Services in the Capital Region of Denmark, Copenhagen, Denmark.; Institute of Biological Psychiatry, Mental Health Center Sct. Hans, Mental Health Services Copenhagen, Roskilde, Denmark., Thomas JJ; Harvard Medical School, Boston, Massachusetts, USA.; Mass General Brigham Eating Disorders Research Collaborative, Boston, Massachusetts, USA.; Eating Disorders Clinical and Research Program, Massachusetts General Hospital, Boston, Massachusetts, USA., Lawson EA; Harvard Medical School, Boston, Massachusetts, USA.; Mass General Brigham Eating Disorders Research Collaborative, Boston, Massachusetts, USA.; Neuroendocrine Unit, Division of Endocrinology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
Jazyk: angličtina
Zdroj: The International journal of eating disorders [Int J Eat Disord] 2024 Jun 28. Date of Electronic Publication: 2024 Jun 28.
DOI: 10.1002/eat.24243
Abstrakt: Objective: Avoidant/restrictive food intake disorder (ARFID) is common among populations with nutrition-related medical conditions. Less is known about the medical comorbidity/complication frequencies in youth with ARFID. We evaluated the medical comorbidities and metabolic/nutritional markers among female and male youth with full/subthreshold ARFID across the weight spectrum compared with healthy controls (HC).
Method: In youth with full/subthreshold ARFID (n = 100; 49% female) and HC (n = 58; 78% female), we assessed self-reported medical comorbidities via clinician interview and explored abnormalities in metabolic (lipid panel and high-sensitive C-reactive protein [hs-CRP]) and nutritional (25[OH] vitamin D, vitamin B12, and folate) markers.
Results: Youth with ARFID, compared with HC, were over 10 times as likely to have self-reported gastrointestinal conditions (37% vs. 3%; OR = 21.2; 95% CI = 6.2-112.1) and over two times as likely to have self-reported immune-mediated conditions (42% vs. 24%; OR = 2.3; 95% CI = 1.1-4.9). ARFID, compared with HC, had a four to five times higher frequency of elevated triglycerides (28% vs. 12%; OR = 4.0; 95% CI = 1.7-10.5) and hs-CRP (17% vs. 4%; OR = 5.0; 95% CI = 1.4-27.0) levels.
Discussion: Self-reported gastrointestinal and certain immune comorbidities were common in ARFID, suggestive of possible bidirectional risk/maintenance factors. Elevated cardiovascular risk markers in ARFID may be a consequence of limited dietary variety marked by high carbohydrate and sugar intake.
(© 2024 Wiley Periodicals LLC.)
Databáze: MEDLINE
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