APOLIPOPROTEIN E GENE POLYMORPHISMS AND PLASMA LIPIDS IN PERSONS LIVING WITH HIV: A CROSS SECTIONAL STUDY.

Autor:	Kuti MA; Department of Chemical Pathology, College of Medicine, University of Ibadan/University College Hospital, Ibadan., Bamidele OT; Department of Chemical Pathology, Babcock University, Ilishan Remo, Ogun State., Nduka NS; Department of Chemical Pathology, College of Medicine, University of Ibadan, Ibadan., Olaniyi O; Infectious Diseases Institute, College of Medicine, University of Ibadan, Ibadan., Ogundeji OA; Department of Chemical Pathology, University College Hospital, Ibadan., Adedapo KS; Department of Chemical Pathology, College of Medicine, University of Ibadan/University College Hospital, Ibadan., Awolude OA; Department of Obstetrics and Gynaecology/Infectious Diseases Institute, College of Medicine, University of Ibadan/University College Hospital, Ibadan.
Jazyk:	angličtina
Zdroj:	Annals of Ibadan postgraduate medicine [Ann Ib Postgrad Med] 2024 Apr 30; Vol. 22 (1), pp. 8-13.
Abstrakt:	Background and Objective: A major modifiable risk factor for atherosclerotic cardiovascular disease is abnormalities in lipid and lipoprotein metabolism which are frequently seen in HIV as well as its treatment. Apo-E is a protein that is important in plasma lipid homeostasis and its genetic alleles have been shown to contribute to lipid abnormalities. We examined for the effect of Apo-E gene polymorphisms on plasma lipid levels in PLHIV on protease inhibitor therapy. Methods: This was a cross-sectional study conducted among adult persons living with HIV. Lipid profile, Apo-B and Apo-A were measured in fasting plasma. Amplification and analysis of Apo-E genotypes were determined using the Seeplex Apo-E ACE genotyping kit. Differences in quantitative values were compared with non-parametric analysis methods. Results: Eighty-four persons were recruited into the study, 75% of whom were virally suppressed. The 3 homozygous genotypes had significantly different levels of low-density lipoprotein cholesterol (LDL-C), Apolipoprotein B (Apo-B) and Apolipoprotein A1 (Apo-A1). Persons with apo ε2/ε2 had higher LDL-C compared to those with apo ε3/ε3 (3.26 (3.61) mmol/L vs. 2.76 (1.28) mmol/L, p = 0.010). Those with apo ε4/ε4 had lower Apo-A1 compared to those with apo ε3/ε3 (0.84 (0.48) g/dL vs. 1.27 (0.70) g/dL, p =0.009). Compared with the same group, the heterozygous genotype, apo ε2/ε3 had lower triglyceride levels :1.33 (0.65) mmol/ L vs. 1.86 (1.11) mmol/L, p = 0.045. Conclusion: Polymorphisms in the Apo-E gene may have significant influences on plasma lipid and apolipoprotein levels in PLHIV on PI therapy. This may have implications for the assessment of risk for cardiovascular disease. Competing Interests: The authors declare no competing interest (© Association of Resident Doctors, UCH, Ibadan.)
Databáze:	MEDLINE
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