Exploring the Relationship Between Helicobacter pylori Infection and Biliary Diseases: A Comprehensive Analysis Using the United States National Inpatient Sample (2016-2020).
| Autor: | Ahmad SO; Department of Medicine, Brigham and Women's Hospital, Boston, USA., AlAmr M; Department of Family Medicine, Dr. Sulaiman Al Habib Medical Group, Riyadh, SAU., Taftafa A; College of Medicine, Alfaisal University, Riyadh, SAU., AlMazmomy AM; College of Medicine, King Abdulaziz University, Rabigh, SAU., Alkahmous N; College of Medicine, Vision Colleges, Riyadh, SAU., Alharran AM; College of Medicine and Medical Science, Arabian Gulf University, Manama, BHR., Almarri AM; College of Medicine and Medical Science, Arabian Gulf University, Manama, BHR., Alyaqout F; College of Medicine and Medical Science, Arabian Gulf University, Manama, BHR., Saad AR; College of Medicine and Medical Science, Arabian Gulf University, Manama, BHR., Alazmi AM; College of Medicine and Medical Science, Arabian Gulf University, Manama, BHR., Alharran YM; Faculty of Medicine, Alexandria University, Alexandria, EGY., Abotela M; Faculty of Medicine, Alexandria University, Alexandria, EGY., Abu-Zaid A; College of Medicine, Alfaisal University, Riyadh, SAU. |
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| Jazyk: | angličtina |
| Zdroj: | Cureus [Cureus] 2024 May 28; Vol. 16 (5), pp. e61238. Date of Electronic Publication: 2024 May 28 (Print Publication: 2024). |
| DOI: | 10.7759/cureus.61238 |
| Abstrakt: | Background: Helicobacter pylori ( H. pylori ) infection is widely recognized for its association with gastric diseases. Prior studies on the relationship between H. pylori infection and biliary diseases have faced constraints, including inadequate control of confounding factors and small sample sizes. This study aims to explore the association between H. pylori infection and biliary diseases using a large, population-based sample with adequate control for various covariates. Methods: The National Inpatient Sample (NIS) from 2016 to 2020 was used to investigate the association between H. pylori infection and biliary diseases. We identified patients with H. pylori infection using the International Classification of Diseases, Tenth Revision (ICD-10) code (B96.81). Descriptive analysis and inferential statistics, including univariate and multivariate regression, were performed to explore the relationship between H. pylori and selected biliary diseases. Results: Overall, 32,966,720 patients were analyzed. Among them, 736,585 patients had biliary diseases (n=1,637 with H. pylori and n=734,948 without H. pylori ). The baseline characteristics revealed notable differences in demographics and healthcare variables between both groups. Univariate regression analysis demonstrated significant associations between H. pylori infection and various biliary diseases such as gallbladder stones, gallbladder cancer, cholangitis, acute cholecystitis, and biliary pancreatitis, with the highest risk for chronic cholecystitis (odds ratio: 5.21; 95% confidence interval: 4.1-6.62; p<0.0001). Multivariate regression analysis, after adjusting for various covariates, confirmed these associations, providing insights into the potential causal relationship between H. pylori and biliary diseases. Conclusion: This study strengthens the evidence suggesting a potential association between H. pylori infection and biliary diseases. The findings need to be validated in prospective clinical studies. Competing Interests: Human subjects: Consent was obtained or waived by all participants in this study. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. (Copyright © 2024, Ahmad et al.) |
| Databáze: | MEDLINE |
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