Triiodothyronine supplementation in a sheep model of intensive care.

Autor: Maiden MJ; Discipline of Acute Care Medicine, Adelaide Medical School, The University of Adelaide, Adelaide, South Australia 5005, Australia.; Intensive Care Unit, Royal Adelaide Hospital, Central Adelaide Local Health Network, Adelaide, South Australia 5000, Australia.; Intensive Care Unit, Royal Melbourne Hospital, Parkville, Victoria 3052, Australia.; Department of Critical Care, Melbourne Medical School, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Parkville, Victoria 3052, Australia., Torpy DJ; Endocrine and Metabolic Unit, Department of Medicine, Royal Adelaide Hospital, Central Adelaide Local Health Network, Adelaide, South Australia 5000, Australia.; Discipline of Medicine, Adelaide Medical School, The University of Adelaide, Adelaide, South Australia 5005, Australia., Ludbrook GL; Discipline of Acute Care Medicine, Adelaide Medical School, The University of Adelaide, Adelaide, South Australia 5005, Australia.; Department of Anaesthesia, Royal Adelaide Hospital, Central Adelaide Local Health Network, Adelaide, South Australia 5000, Australia., Clarke IJ; Department of Physiology, Faculty of Science, Monash University, Clayton, Victoria 3800, Australia.; School of Agriculture, Food and Ecosystems Science, The University of Melbourne, Parkville, Victoria 3052, Australia., Chacko B; Intensive Care Unit, Royal Adelaide Hospital, Central Adelaide Local Health Network, Adelaide, South Australia 5000, Australia.; Department of Critical Care, Christian Medical College, Vellore, Tamil Nadu 632004, India., Nash CH; Discipline of Acute Care Medicine, Adelaide Medical School, The University of Adelaide, Adelaide, South Australia 5005, Australia., Matthews L; Preclinical, Imaging and Research Laboratories, South Australian Health and Medical Research Institute, Hillcrest, South Australia 5086, Australia., Porter S; Preclinical, Imaging and Research Laboratories, South Australian Health and Medical Research Institute, Hillcrest, South Australia 5086, Australia., Kuchel TR; Preclinical, Imaging and Research Laboratories, South Australian Health and Medical Research Institute, Hillcrest, South Australia 5086, Australia.
Jazyk: angličtina
Zdroj: Experimental and therapeutic medicine [Exp Ther Med] 2024 Jun 17; Vol. 28 (2), pp. 321. Date of Electronic Publication: 2024 Jun 17 (Print Publication: 2024).
DOI: 10.3892/etm.2024.12611
Abstrakt: Triiodothyronine (T3) concentrations in plasma decrease during acute illness and it is unclear if this contributes to disease. Clinical and laboratory studies of T3 supplementation in disease have revealed little or no effect. It is uncertain if short term supplementation of T3 has any discernible effect in a healthy animals. Observational study of intravenous T3 (1 µg/kg/h) for 24 h in a healthy sheep model receiving protocol-guided intensive care supports (T3 group, n=5). A total of 45 endpoints were measured including hemodynamic, respiratory, renal, hematological, metabolic and endocrine parameters. Data were compared with previously published studies of sheep subject to the same support protocol without administered T3 (No T3 group, n=5). Plasma free T3 concentrations were elevated 8-fold by the infusion (pmol/l at 24 h; T3 group 34.9±9.9 vs. No T3 group 4.4±0.3, P<0.01, reference range 1.6 to 6.8). There was no significant physiological response to administration of T3 over the study duration. Supplementation of intravenous T3 for 24 h has no physiological effect on relevant physiological endpoints in healthy sheep. Further research is required to understand if the lack of effect of short-term T3 may be related to kinetics of T3 cellular uptake, metabolism and action, or acute counterbalancing hormone resistance. This information may be helpful in design of clinical T3 supplementation trials.
Competing Interests: The authors declare that they have no competing interests.
(Copyright © 2024, Spandidos Publications.)
Databáze: MEDLINE
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