Mechanistic Rationale for Ketene Formation during Dabbing and Vaping.

Autor:	Munger KR; Department of Chemistry, Portland State University, Portland, Oregon 97217, United States., Anreise KM; Department of Chemistry, Portland State University, Portland, Oregon 97217, United States., Jensen RP; Florascience Inc., Milwaukie, Oregon 97222, United States., Peyton DH; Department of Chemistry, Portland State University, Portland, Oregon 97217, United States., Strongin RM; Department of Chemistry, Portland State University, Portland, Oregon 97217, United States.
Jazyk:	angličtina
Zdroj:	JACS Au [JACS Au] 2024 Jun 12; Vol. 4 (6), pp. 2403-2410. Date of Electronic Publication: 2024 Jun 12 (Print Publication: 2024).
DOI:	10.1021/jacsau.4c00436
Abstrakt:	Ketene is one of the most toxic vaping emissions identified to date. However, its high reactivity renders it relatively challenging to identify. In addition, certain theoretical studies have shown that realistic vaping temperature settings may betoo low to produce ketene. Each of these issues is addressed herein. First, an isotopically labeled acetate precursor is used for the identification of ketene with enhanced rigor in vaped aerosols. Second, discrepancies between theoretical and experimental findings are explained by accounting for the effects of aerobic (experimental) versus anaerobic (simulated and theoretical) pyrolysis conditions. This finding is also relevant to explaining the relatively low-temperature production of aerosol toxicants beyond ketene. Moreover, the study presented herein shows that ketene formation during vaping is not limited to molecules possessing a phenyl acetate substructure. This means that ketene emission during vaping, including from popular flavorants such as ethyl acetate, may be more prevalent than is currently known. Competing Interests: The authors declare no competing financial interest. (© 2024 The Authors. Published by American Chemical Society.)
Databáze:	MEDLINE
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