Extracellular vesicles and lipoproteins - Smart messengers of blood cells in the circulation.

Autor: Nguyen PHD; Department of Pharmacology and Institute for Digital Medicine Yong Loo Lin School of Medicine National University of Singapore Singapore Singapore., Le AH; Department of Pharmacology and Institute for Digital Medicine Yong Loo Lin School of Medicine National University of Singapore Singapore Singapore., Pek JSQ; Department of Pharmacology and Institute for Digital Medicine Yong Loo Lin School of Medicine National University of Singapore Singapore Singapore., Pham TT; Department of Pharmacology and Institute for Digital Medicine Yong Loo Lin School of Medicine National University of Singapore Singapore Singapore., Jayasinghe MK; Department of Pharmacology and Institute for Digital Medicine Yong Loo Lin School of Medicine National University of Singapore Singapore Singapore.; Immunology Programme Cancer Programme and Nanomedicine Translational Programme Yong Loo Lin School of Medicine National University of Singapore Singapore Singapore.; Department of Surgery Yong Loo Lin School of Medicine National University of Singapore Singapore Singapore., Do DV; Department of Pharmacology and Institute for Digital Medicine Yong Loo Lin School of Medicine National University of Singapore Singapore Singapore., Phung CD; Department of Pharmacology and Institute for Digital Medicine Yong Loo Lin School of Medicine National University of Singapore Singapore Singapore., Le MTN; Department of Pharmacology and Institute for Digital Medicine Yong Loo Lin School of Medicine National University of Singapore Singapore Singapore.; Immunology Programme Cancer Programme and Nanomedicine Translational Programme Yong Loo Lin School of Medicine National University of Singapore Singapore Singapore.; Department of Surgery Yong Loo Lin School of Medicine National University of Singapore Singapore Singapore.
Jazyk: angličtina
Zdroj: Journal of extracellular biology [J Extracell Biol] 2022 Jul 05; Vol. 1 (7), pp. e49. Date of Electronic Publication: 2022 Jul 05 (Print Publication: 2022).
DOI: 10.1002/jex2.49
Abstrakt: Blood cell-derived extracellular vesicles (BCEVs) and lipoproteins are the major circulating nanoparticles in blood that play an important role in intercellular communication. They have attracted significant interest for clinical applications, given their endogenous characteristics which make them stable, biocompatible, well tolerated, and capable of permeating biological barriers efficiently. In this review, we describe the basic characteristics of BCEVs and lipoproteins and summarize their implications in both physiological and pathological processes. We also outline well accepted workflows for the isolation and characterization of these circulating nanoparticles. Importantly, we highlight the latest progress and challenges associated with the use of circulating nanoparticles as diagnostic biomarkers and therapeutic interventions in multiple diseases. We spotlight novel engineering approaches and designs to facilitate the development of these nanoparticles by enhancing their stability, targeting capability, and delivery efficiency. Therefore, the present work provides a comprehensive overview of composition, biogenesis, functions, and clinical translation of circulating nanoparticles from the bench to the bedside.
Competing Interests: Minh T.N. Le is a scientific co‐founder, advisor and shareholder of Carmine Therapeutics, a company that develops extracellular‐vesicle‐based therapies. Other authors declare no conflict of interest.
(© 2022 The Authors. Journal of Extracellular Biology published by Wiley Periodicals, LLC on behalf of the International Society for Extracellular Vesicles.)
Databáze: MEDLINE
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