A case of equine multicentric lymphoma: Clinical, microscopical, and molecular findings.

Autor: Silva GF; ICBAS School of Medicine and Biomedical Sciences, Porto University, Porto, Portugal., Ribeiro TE; ICBAS School of Medicine and Biomedical Sciences, Porto University, Porto, Portugal.; Equine Clinical Centre of Vairão (CCEV), Vairão, Portugal., Cunha R; ICBAS School of Medicine and Biomedical Sciences, Porto University, Porto, Portugal.; Equine Clinical Centre of Vairão (CCEV), Vairão, Portugal.; AL4animals, Associate Laboratory for Animal and Veterinary Sciences, Lisbon, Portugal., Salas PB; ICBAS School of Medicine and Biomedical Sciences, Porto University, Porto, Portugal.; Equine Clinical Centre of Vairão (CCEV), Vairão, Portugal., Guimarães T; ICBAS School of Medicine and Biomedical Sciences, Porto University, Porto, Portugal.; Equine Clinical Centre of Vairão (CCEV), Vairão, Portugal.; AL4animals, Associate Laboratory for Animal and Veterinary Sciences, Lisbon, Portugal., Ribeiro MR; ICBAS School of Medicine and Biomedical Sciences, Porto University, Porto, Portugal., Barros G; ICBAS School of Medicine and Biomedical Sciences, Porto University, Porto, Portugal., Carvalho F; ICBAS School of Medicine and Biomedical Sciences, Porto University, Porto, Portugal., Mesquita JR; ICBAS School of Medicine and Biomedical Sciences, Porto University, Porto, Portugal.; Epidemiology Research Unit (EPIUnit), Institute of Public Health of the University of Porto, Porto, Portugal.; Laboratory for Integrative and Translational Research in Population Health (ITR), Porto, Portugal., Amorim I; ICBAS School of Medicine and Biomedical Sciences, Porto University, Porto, Portugal.; Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal.; Institute for Research and Innovation in Health (i3S), Porto, Portugal.
Jazyk: angličtina
Zdroj: Open veterinary journal [Open Vet J] 2024 May; Vol. 14 (5), pp. 1294-1301. Date of Electronic Publication: 2024 May 31.
DOI: 10.5455/OVJ.2024.v14.i5.24
Abstrakt: Background: Although relatively uncommon, lymphoma is the most prevalent haematopoietic neoplasia in horses, and multicentric lymphoma remains the most common presentation of the disease. The pathogenesis of equine lymphoma is still poorly understood and the diagnosis is usually confirmed at an advanced stage of the disease, compromising the prognosis. This study investigated the clinical, pathological, and molecular features of a case of equine multicentric lymphoma.
Case Description: An apparently healthy 5-year-old crossbreed mare hospitalized at the Centre of Animal Reproduction of Vairão, Portugal, suddenly presented clinical signs of supraorbital oedema and mandibular lymph node enlargement, developing fever, facial oedema, and generalized lymphadenopathy. The mare ended up dying twenty-four days after the first clinical signs due to multisystem organ failure. Haematological and biochemical analyses, necropsy, and microscopic and molecular evaluation of affected tissues were performed. At necropsy, the main findings were multiple multinodular lesions, distributed along the serous surface of oropharynx, trachea, pericardium, gastrointestinal tract, and mesentery. Microscopically, these consisted of solid proliferations of neoplastic round cells that exhibited immunopositivity for CD3 (T cells). Based on these findings, a medium-grade multicentric T-cell lymphoma was diagnosed.
Conclusion: There is still very little research regarding the molecular characterization of lymphoma in horses. As an entity itself is quite heterogeneous, it is important to describe the interspecies particularities to understand its development and behaviour.
Competing Interests: The authors declare that there is no conflict of interest.
Databáze: MEDLINE
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