Impact of helminth infections during pregnancy on maternal and newborn Vitamin D and on birth outcomes.

Autor: Berry SPD; Institute for Medical Microbiology, Immunology and Hygiene, TUM School of Medicine and Health, Technical University of Munich (TUM), Trogerstrasse 30, 81675, Munich, Germany.; Centre de Recherches Médicales de Lambaréné, Lambaréné, Gabon.; Center for Global Health, TUM School of Medicine and Health, Technical University of Munich (TUM), Munich, Germany., Honkpèhedji YJ; Centre de Recherches Médicales de Lambaréné, Lambaréné, Gabon.; Department of Parasitology, Leiden University Medical Centre, Leiden, The Netherlands.; Institut Für Tropenmedizin, Universität Tübingen, Tübingen, Germany.; Fondation Pour La Recherche Scientifique (FORS), Cotonou, Benin., Ludwig E; Institute for Medical Microbiology, Immunology and Hygiene, TUM School of Medicine and Health, Technical University of Munich (TUM), Trogerstrasse 30, 81675, Munich, Germany.; Center for Global Health, TUM School of Medicine and Health, Technical University of Munich (TUM), Munich, Germany., Mahmoudou S; Centre de Recherches Médicales de Lambaréné, Lambaréné, Gabon., Prodjinotho UF; Institute for Medical Microbiology, Immunology and Hygiene, TUM School of Medicine and Health, Technical University of Munich (TUM), Trogerstrasse 30, 81675, Munich, Germany.; Center for Global Health, TUM School of Medicine and Health, Technical University of Munich (TUM), Munich, Germany., Adamou R; Centre de Recherches Médicales de Lambaréné, Lambaréné, Gabon., Nouatin OP; Institut de Recherche Clinique du Bénin (IRCB), Abomey-Calavi, Benin., Adégbitè BR; Centre de Recherches Médicales de Lambaréné, Lambaréné, Gabon.; Institut Für Tropenmedizin, Universität Tübingen, Tübingen, Germany., Dejon-Agobe JC; Centre de Recherches Médicales de Lambaréné, Lambaréné, Gabon.; Institut Für Tropenmedizin, Universität Tübingen, Tübingen, Germany., Mba RB; Centre de Recherches Médicales de Lambaréné, Lambaréné, Gabon., Maloum M; Centre de Recherches Médicales de Lambaréné, Lambaréné, Gabon., Nkoma AMM; Centre de Recherches Médicales de Lambaréné, Lambaréné, Gabon., Zinsou JF; Centre de Recherches Médicales de Lambaréné, Lambaréné, Gabon.; Institut Für Tropenmedizin, Universität Tübingen, Tübingen, Germany.; Fondation Pour La Recherche Scientifique (FORS), Cotonou, Benin., Luty AJF; MERIT, IRD, Université Paris Cité, Paris, France., Esen M; Centre de Recherches Médicales de Lambaréné, Lambaréné, Gabon.; Institut Für Tropenmedizin, Universität Tübingen, Tübingen, Germany.; German Center for Infection Research (DZIF), Partner site Tübingen, Tübingen, Germany., Adégnika AA; Centre de Recherches Médicales de Lambaréné, Lambaréné, Gabon.; Institut Für Tropenmedizin, Universität Tübingen, Tübingen, Germany.; Fondation Pour La Recherche Scientifique (FORS), Cotonou, Benin.; German Center for Infection Research (DZIF), Partner site Tübingen, Tübingen, Germany., Prazeres da Costa C; Institute for Medical Microbiology, Immunology and Hygiene, TUM School of Medicine and Health, Technical University of Munich (TUM), Trogerstrasse 30, 81675, Munich, Germany. Clarissa.daCosta@tum.de.; Center for Global Health, TUM School of Medicine and Health, Technical University of Munich (TUM), Munich, Germany. Clarissa.daCosta@tum.de.; German Center for Infection Research (DZIF), Partner site Munich, Munich, Germany. Clarissa.daCosta@tum.de.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2024 Jun 27; Vol. 14 (1), pp. 14845. Date of Electronic Publication: 2024 Jun 27.
DOI: 10.1038/s41598-024-65232-9
Abstrakt: Poor birth outcomes in low- and middle income countries are associated with maternal vitamin D deficiency and chronic helminth infections. Here, we investigated whether maternal Schistosoma haematobium affects maternal or cord vitamin D status as well as birth outcomes. In a prospective cross-sectional study of pregnant women conducted in Lambaréné, Gabon, we diagnosed maternal parasitic infections in blood, urine and stool. At delivery we measured vitamin D in maternal and cord blood. S. haematobium, soil-transmitted helminths, and microfilariae were found at prevalences of 30.2%, 13.0%, and 8.8%, respectively. Insufficient vitamin D and calcium levels were found in 28% and 15% of mothers, and in 11.5% and 1.5% of newborns. Mothers with adequate vitamin D had lower risk of low birthweight babies (aOR = 0.11, 95% CI 0.02-0.52, p = 0.01), whilst offspring of primipars had low cord vitamin D levels, and low vitamin D levels increased the risk of maternal inflammation. Maternal filariasis was associated with low calcium levels, but other helminth infections affected neither vitamin D nor calcium levels in either mothers or newborns. Healthy birth outcomes require maintenance of adequate vitamin D and calcium levels. Chronic maternal helminth infections do not disrupt those levels in a semi-rural setting in sub-Saharan Africa.
(© 2024. The Author(s).)
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje