The effect of vitamin E on ethanol-induced liver damage in rats.

Autor: Kooshki S; Department of Cellular and Molecular Biology, School of Biology, Damghan University, Damghan, Iran., Mirzaeian L; Department of Embryology, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran. Lmirzaey64@gmail.com., Malakhond MK; Department of Medical Education Management, Yasuj University of Medical Sciences, Yasuj, Iran., Goudarzi I; Department of Cellular and Molecular Biology, School of Biology, Damghan University, Damghan, Iran., Ghorbanian MT; Department of Cellular and Molecular Biology, School of Biology, Damghan University, Damghan, Iran. Ghorbanian@du.ac.ir.
Jazyk: angličtina
Zdroj: Biologia futura [Biol Futur] 2024 Dec; Vol. 75 (4), pp. 425-435. Date of Electronic Publication: 2024 Jun 27.
DOI: 10.1007/s42977-024-00226-2
Abstrakt: Ethanol can have harmful effects on the development of the embryos. The aim of this study was to evaluate the effect of vitamin E, as an antioxidant, on changes in liver tissue damaged by ethanol in rats. Rats were divided into 11 groups, control, naive, sunflower oil (oil), ethanol, vitamin E (100, 200, and 400 mg/kg), ethanol + vitamin E (100, 200, and 400 mg/kg), and oily ethanol. In the experimental groups, rats received ethanol (v/v 40%) and vitamin E (100, 200, and 400 mg/kg) orally once a day from gestational day 0 to 28 days after delivery. Then, we evaluated the weight of rats and their offspring, the number of offspring, and the level of malondialdehyde (MDA), as an index of lipid peroxidation, superoxide dismutase (SOD), and glutathione peroxidase (GPX), as antioxidant enzymes, in the liver tissue of the offspring. Vitamin E significantly increases in weight of pregnant mothers and their offspring on the 21st day of pregnancy. The level of MDA in the groups receiving vitamin E was significantly reduced compared to the ethanol group. The activity of GPx and SOD antioxidants enzymes was significantly increased in the offspring. Vitamin E could reduce ethanol-induced liver damage in male offspring by reducing oxidative stress.
Competing Interests: Declarations. Ethical approval: All animal experiments were approved by the ethical committee of Damghan University (Ethical code: IR.I AU.SRB.REC.1398.2112).
(© 2024. Akadémiai Kiadó Zrt.)
Databáze: MEDLINE
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